{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:43:59Z","timestamp":1777934639426,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>There remains a need to determine whether certain subgroups of newly diagnosed multiple myeloma (NDMM) derive the same benefit from high-dose chemotherapy\u2013autologous stem cell transplant (HDT-ASCT). We describe our institutional experience highlighting the impact of age, obesity, and renal impairment on outcomes after HDT-ASCT for patients with NDMM in a real-world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 449 consecutive patients were included in this retrospective analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No difference in median progression free survival or overall survival was seen for patients with age\u2009&gt;\u200965, body mass index (BMI)\u2009&gt;\u200930\u2005kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , or estimated glomerular filtration rate\u2009&lt;\u200960\u2005mL\/min\/1.73\u2005m\n                      <jats:sup>2<\/jats:sup>\n                      when compared to those without these characteristics. From a safety standpoint, there were no differences in the incidence of transplant-related mortality or secondary malignancy among subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For patients with NDMM undergoing HDT-ASCT, there is no difference in outcomes based on age, BMI, or renal function, and the presence of one or more of these factors should not preclude patients from HDT-ASCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552231224361","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:56:45Z","timestamp":1704243405000},"page":"72-80","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of age, obesity, and renal impairment on outcomes after autologous stem cell transplantation for patients with newly diagnosed multiple myeloma"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9280-4502","authenticated-orcid":false,"given":"Kelly J","family":"Gaffney","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan K.","family":"Bakos","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Velayati","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7978-1652","authenticated-orcid":false,"given":"James A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aswani","family":"Thurlapati","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Weeda","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katelynn","family":"Granger","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coleen","family":"Butcher","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor","family":"Herrington","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deidra","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian T","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4129-5867","authenticated-orcid":false,"given":"Hamza","family":"Hashmi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Medical University of South Carolina, Charleston, SC, 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