{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:01:30Z","timestamp":1787918490321,"version":"build-2784847793"},"reference-count":52,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Natural and synthetic cannabinoids are being used worldwide to treat various symptoms in cancer patients. This study aims to map the therapeutic benefits and adverse effects associated with the use of cannabis-based drugs in these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following Joanna Briggs Institute guidelines a scoping review was conducted. The study protocol was available in the Open Science Framework public repository. An extensive search strategy involving databases like Cochrane Library, Embase, CINAHL, Medline\/PubMed, Lilacs, Google Scholar, and Open Gray for gray literature analysis was executed by a skilled librarian. The inclusion criteria were primary studies (observational and randomized) that evaluated the efficacy and safety of cannabinoids in cancer patients. The review encompassed studies of diverse designs, publication years, and types, as long as they addressed cannabinoids\u2019 impact in oncology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-nine (82.86%) out of total of 35 were randomized and 6 (14.14%) were non-randomized. About 57.1% of studies utilized registered products as interventions, with THC being the most natural cannabinoid cited in variable doses and administration routes. Moreover, 62.85% of studies specified the cancer types (breast, lung, sarcomas, hematological and reproductive system), while only one study detailed cancer staging. The evaluated outcomes encompassed nausea and vomiting (77.14%), appetite (11.43%), pain (8.57%), and tumor regression (2.86%) across different proportions of studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cannabinoids show promise in managing pain, emesis, and anorexia\/cachexia linked to cancer progression. New randomized clinical trials with a larger number of participants and observational studies on long-term safety are crucial to affirm their medicinal utility for cancer patients unresponsive to conventional drugs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552241239006","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T08:40:52Z","timestamp":1710319252000},"page":"737-751","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Medical cannabis use in oncology and associated outcomes: A scoping review"],"prefix":"10.1177","volume":"30","author":[{"given":"Ana Carolina","family":"Valente","sequence":"first","affiliation":[{"name":"Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9186-110X","authenticated-orcid":false,"given":"Luis Phillipe Nagem","family":"Lopes","sequence":"additional","affiliation":[{"name":"University of Sorocaba, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eline","family":"Matheus","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"bibr1-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.09.004"},{"key":"bibr2-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113871"},{"key":"bibr3-10781552241239006","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2018.3532"},{"key":"bibr4-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105302"},{"key":"bibr5-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1983.247"},{"key":"bibr6-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09378-7"},{"key":"bibr7-10781552241239006","doi-asserted-by":"publisher","DOI":"10.4103\/apjon.apjon-2126"},{"key":"bibr8-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.01.004"},{"key":"bibr9-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.07.020"},{"key":"bibr10-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.5.1932"},{"key":"bibr11-10781552241239006","unstructured":"Jonna Griggs Institute. Chapter 11: Scoping reviews - JBI Manual for Evidence Synthesis - JBI Global Wiki, https:\/\/jbi-global-wiki.refined.site\/space\/MANUAL\/4687342\/Chapter+11%3A+Scoping+reviews (accessed 4 January 2023)."},{"key":"bibr12-10781552241239006","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"bibr13-10781552241239006","unstructured":"Souza ACVEde. Applicability of cannabinoids in oncology: protocol for a systematic scoping review. Epub ahead of print 11 January 2022. DOI:https:\/\/doi.org\/10.17605\/OSF.IO\/PG9J5."},{"key":"bibr14-10781552241239006","volume":"368","author":"Campbell M","year":"2020","journal-title":"Br Med J"},{"key":"bibr15-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq727"},{"key":"bibr16-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.06.008"},{"key":"bibr17-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-005-1063-x"},{"key":"bibr18-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1185\/030079907X167525"},{"key":"bibr19-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199012000-00006"},{"key":"bibr20-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(91)90026-Z"},{"key":"bibr21-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1007\/BF00175407"},{"key":"bibr22-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(88)90300-8"},{"key":"bibr23-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198708000-00014"},{"key":"bibr24-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1007\/BF01728184"},{"key":"bibr25-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198504000-00006"},{"key":"bibr26-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(82)80035-2"},{"key":"bibr27-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(83)90032-9"},{"key":"bibr28-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(82)80032-7"},{"key":"bibr29-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(82)80036-4"},{"key":"bibr30-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(82)80038-8"},{"key":"bibr31-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197510162931603"},{"key":"bibr32-10781552241239006","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1979.tb127271.x"},{"key":"bibr33-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810401)47:7<1746::AID-CNCR2820470704>3.0.CO;2-4"},{"key":"bibr34-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1177\/2049463717710042"},{"key":"bibr35-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.02.018"},{"key":"bibr36-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.1847"},{"key":"bibr37-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.2.567"},{"key":"bibr38-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(82)80383-8"},{"key":"bibr39-10781552241239006","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-6-825"},{"key":"bibr40-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1177\/082585979401000105"},{"key":"bibr41-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603236"},{"key":"bibr42-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)00194-B"},{"key":"bibr43-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(84)80088-4"},{"key":"bibr44-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1981.tb02577.x"},{"key":"bibr45-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198512000-00014"},{"key":"bibr46-10781552241239006","volume":"366","author":"Sterne JAC","year":"2019","journal-title":"Br Med J"},{"key":"bibr47-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0647"},{"key":"bibr48-10781552241239006","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2016.ed61"},{"key":"bibr49-10781552241239006","first-page":"232","volume":"5","author":"Rao KV","year":"2012","journal-title":"Am Health Drug Benefits"},{"key":"bibr50-10781552241239006","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-3079"},{"key":"bibr51-10781552241239006","first-page":"514","volume":"42","author":"Ventola CL","year":"2017","journal-title":"P T"},{"key":"bibr52-10781552241239006","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S156279"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552241239006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552241239006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552241239006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:29:39Z","timestamp":1777688979000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552241239006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,13]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/10781552241239006"],"URL":"https:\/\/doi.org\/10.1177\/10781552241239006","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,13]]}}}