{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:44:59Z","timestamp":1777934699632,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:00:00Z","timestamp":1722556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This longitudinal study aimed to evaluate the overall efficacy of mouthwashes in oral mucositis pain and mucositis xerostomia in advanced nasopharyngeal carcinoma (NPC) patients undergoing concurrent chemoradiotherapy (CCRT) at different phases throughout treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A longitudinal study enrolled 79 advanced NPC subjects receiving CCRT. The subjects were interviewed prospectively three times over 7\u2005weeks for pain and xerostomia scores based on the various types of mouthwash used. The median pain score difference and median xerostomia score difference were utilised to determine mouthwash superiority.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants completed three interviews, during which 480 instances of mouthwash use were observed throughout different phases of the treatment period. The results showed that the median pain scores between mouthwashes differed significantly,\n                      <jats:italic toggle=\"yes\">H<\/jats:italic>\n                      -Stat(3)\u2009=\u200930.0, 25.7 and 26.0, respectively, with\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for all three interviews. The pain score reductions of lidocaine mouthwash (median\u2009=\u20092, interquartile range (IQR)\u2009=\u20093, 2 and 2.75 over the three interviews, respectively) were significantly higher than those of benzydamine and sodium bicarbonate mouthwashes. There were no significant differences between the studied mouthwashes in their xerostomia score reductions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lidocaine mouthwash was superior in managing oral mucositis pain at all phases throughout the entire chemoradiotherapy treatment for advanced NPC patients. There was insufficient evidence to determine the preferred mouthwash for treating oral mucositis xerostomia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552241265933","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T19:23:13Z","timestamp":1722626593000},"page":"910-920","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["A longitudinal assessment of major mouthwashes used in alleviating pain and xerostomia among advanced nasopharyngeal carcinoma patients receiving chemoradiotherapy"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6071-4170","authenticated-orcid":false,"given":"Rhubain","family":"Mageswaran","sequence":"first","affiliation":[{"name":"Department of Radiotherapy and Oncology Pharmacy, Kuala Lumpur Hospital, Ministry of Health, Wilayah Persekutuan Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9716-3591","authenticated-orcid":false,"given":"Zen Yang","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology Pharmacy, Kuala Lumpur Hospital, Ministry of Health, Wilayah Persekutuan Kuala Lumpur, Malaysia"},{"name":"Institute for Health Systems Research, National Institutes of Health, Ministry of Health, Shah Alam, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33100"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv202"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01208"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgz003"},{"key":"e_1_3_3_6_2","article-title":"Unveiling the multifaceted management of oral mucositis in cancer patients: a narrative review","volume":"16","author":"Sangavi R","year":"2024","unstructured":"Sangavi R, Pandiyan I. Unveiling the multifaceted management of oral mucositis in cancer patients: a narrative review. Cureus 2024; 16: e55213.","journal-title":"Cureus"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.19.00652"},{"key":"e_1_3_3_8_2","article-title":"Radiation-induced mucositis: a retrospective study of dexamethasone\u2013lidocaine\u2013vitamin B12 mouth rinse versus compound chlorhexidine mouthwash in nasopharyngeal carcinoma","volume":"9","author":"Li K","year":"2023","unstructured":"Li K, Ren X, Xie R. Radiation-induced mucositis: a retrospective study of dexamethasone\u2013lidocaine\u2013vitamin B12 mouth rinse versus compound chlorhexidine mouthwash in nasopharyngeal carcinoma. Heliyon 2023; 9: e15955.","journal-title":"Heliyon"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0278102"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-023-08185-5"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01208"},{"key":"e_1_3_3_12_2","unstructured":"BC Cancer. Symptom Management Guidelines: ORAL MUCOSITIS. [online]. British Columbia: British Columbia Provincial Health Services Authority. 2019. http:\/\/www.bccancer.bc.ca\/nursing-site\/Documents\/12.%20Oral%20Mucositis.pdf."},{"key":"e_1_3_3_13_2","article-title":"Effects of 9 oral care solutions on the prevention of oral mucositis: a network meta-analysis of randomized controlled trials","volume":"99","author":"Yu YT","year":"2020","unstructured":"Yu YT, Deng JL, Jin XR, et al. Effects of 9 oral care solutions on the prevention of oral mucositis: a network meta-analysis of randomized controlled trials. Medicine (Baltimore) 2020; 99: e19661.","journal-title":"Medicine (Baltimore)"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_176_18"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.3504"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.01.010"},{"key":"e_1_3_3_17_2","unstructured":"PDQ\u00ae Supportive and Palliative Care Editorial Board. Oral Complications of Chemotherapy and Head\/Neck Radiation (PDQ\u00ae)\u2014Patient Version. [online]. National Cancer Institute. 2023. https:\/\/www.cancer.gov\/about-cancer\/treatment\/side-effects\/mouth-throat\/oral-complications-pdq."},{"key":"e_1_3_3_18_2","volume-title":"Faces Pain Scale\u2014Revised version (FPS-R). [online]","author":"Hicks C","year":"2001","unstructured":"Hicks C, von Baeyer C, Spafford P, et al. Faces Pain Scale\u2014Revised version (FPS-R). [online]. 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