{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:23:03Z","timestamp":1793906583759,"version":"4.8.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR) are linked with side effects involving skin and mucosa. Herein, we present a unique case of oral lichenoid drug eruption (LDE) in a patient treated with osimertinib.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 75-year-old woman was diagnosed with metastatic EGFR-mutated lung adenocarcinoma, and started on osimertinib 80\u2005mg PO daily. At 24 months of therapy, the patient developed a painful, red, and white striated oral lesion involving the left buccal mucosa and the adjacent buccal aspect of gingivae. Biopsy showed oral LDE. Causality assessment between osimertinib and the oral LDE via Naranjo Adverse Drug Reaction probability scale revealed a score of 5.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management and outcome<\/jats:title>\n                    <jats:p>Osimetinib discontinuation was not felt to be in the best interest of the patient. Therefore, diphenhydramine HCL mouthwash every 6\u2005h PRN (before meals) was started. Spicy and hot foods were discontinued. At a four-week follow-up visit, the patient reported moderate improvement in her symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oral LDEs are considered premalignant lesions as they can transform into squamous cell carcinoma; therefore, regular follow-up is needed. Awareness of this potential side effect of osimertinib would also prevent unnecessary (and potentially costly) work-up and lead to its prompt diagnosis and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552241268693","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T00:50:28Z","timestamp":1722559828000},"page":"1278-1281","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Oral lichenoid drug eruption due to osimertinib for lung cancer"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9508-9911","authenticated-orcid":false,"given":"Ruba","family":"Alchaikh Hassan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Eisenhower Health, Rancho Mirage, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abram","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Eisenhower Health, Rancho Mirage, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-8394","authenticated-orcid":false,"given":"Constantin A.","family":"Dasanu","sequence":"additional","affiliation":[{"name":"Lucy Curci Cancer Center, Eisenhower Health, Rancho Mirage, CA, USA"},{"name":"Department of Medical Oncology and Hematology, University of California in San Diego Health System, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"bibr1-10781552241268693","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr2-10781552241268693","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0425"},{"key":"bibr3-10781552241268693","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1913662"},{"key":"bibr4-10781552241268693","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.570921"},{"key":"bibr5-10781552241268693","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098188"},{"key":"bibr6-10781552241268693","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S168248"},{"key":"bibr7-10781552241268693","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2020.06.010"},{"key":"bibr8-10781552241268693","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18879"},{"key":"bibr9-10781552241268693","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.117315"},{"key":"bibr10-10781552241268693","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0169"},{"key":"bibr11-10781552241268693","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2022.10.005"},{"key":"bibr12-10781552241268693","doi-asserted-by":"publisher","DOI":"10.1186\/s13005-022-00333-2"},{"key":"bibr13-10781552241268693","first-page":"1","volume":"20","author":"Rotaru D","year":"2020","journal-title":"Exp Ther Med"},{"key":"bibr14-10781552241268693","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.09.006"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552241268693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552241268693","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552241268693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:30:07Z","timestamp":1777689007000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552241268693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,1]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1177\/10781552241268693"],"URL":"https:\/\/doi.org\/10.1177\/10781552241268693","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,1]]}}}