{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:44:13Z","timestamp":1777934653416,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Taxanes and platinum are first-line treatments in gynecological tumors with high rates of hypersensitivity reactions (HSRs), leading to discontinuation of treatment. Desensitization involves induction of temporary tolerance to previously sensitized medications. The aims of this study are to describe HSRs to paclitaxel and carboplatin and evaluate the safety and effectiveness of desensitization protocols in gynecological cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Original, retrospective, descriptive, analytical study, approved by Bioethics and Research Committee, included &gt;18-year-old patients with gynecological tumors experiencing HSRs to first-line chemotherapy. Patients underwent 3-bag-12-step desensitization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>174 desensitization (95 paclitaxel, 79 carboplatin) in 33 female patients, mean age 45.5 years (18\u201371y). Cancer diagnosis: breast 8 (24.2%), ovarian 14 (42.2%), endometrial 2 (6.1%) and cervix 9 (27.2%). HSR occurred in paclitaxel during cycles 1\u20132 and in carboplatin after 6 cycles. The most frequently seen HSR symptom was cardiovascular with paclitaxel (94.7%), and cutaneous (93.3%) with carboplatin. Three-bags 12-steps desensitization protocol (initial dilution 1:100) in 5.67hrs. All patients reached total dose desensitization: 82% with no reaction, 12% mild, 6% moderate and 0% severe reaction. Mean disease-free interval and progression-free interval in months (m): breast cancer 29\u2005m and 14\u2005m, ovarian 22\u2005m and 9\u2005m, endometrial 40\u2005m and cervical cancer: 67.5\u2005m and 27\u2005m. Twenty-five patients (73.5%) are still alive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HSRs to paclitaxel manifest in the first 1\u20132 cycles and to carboplatin after 6 cycles. Symptoms include cardiovascular, atypical neuromuscular and urticaria. Changing treatment lines impacts prognosis. Our study revealed that ovarian cancer patients undergoing desensitization protocols achieved longer progression-free intervals. All patients successfully reached total dose desensitization. This study provides evidence of the effectiveness and safety of desensitization and promising perspective for continuing first-line treatment with HSRs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552241269766","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T11:57:55Z","timestamp":1724846275000},"page":"955-964","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and oncological effectiveness after desensitization in patients with previous hypersensitivity reactions to chemotherapy"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6023-6934","authenticated-orcid":false,"given":"Rosalaura V.","family":"Villarreal-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d"},{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3723-8525","authenticated-orcid":false,"given":"Oscar","family":"Vidal-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d"},{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-2428","authenticated-orcid":false,"given":"Javier A.","family":"Mart\u00ednez-Moyano","sequence":"additional","affiliation":[{"name":"Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d"},{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5673-3852","authenticated-orcid":false,"given":"Marianela","family":"Madrazo-Morales","sequence":"additional","affiliation":[{"name":"Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d"},{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7381-3360","authenticated-orcid":false,"given":"Kathia S.","family":"S\u00e1enz-Cant\u00fa","sequence":"additional","affiliation":[{"name":"Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d"},{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2896-9577","authenticated-orcid":false,"given":"Diana E.","family":"Cadenas-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d"},{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6037-5248","authenticated-orcid":false,"given":"Victor M.","family":"Oyervides-Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d"},{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6578-2620","authenticated-orcid":false,"given":"Mar\u00eda Fernanda","family":"Noriega-Iriondo","sequence":"additional","affiliation":[{"name":"Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d"},{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1494-6741","authenticated-orcid":false,"given":"Patricia","family":"Rodr\u00edguez-Ni\u00f1o","sequence":"additional","affiliation":[{"name":"Hospital Universitario \u201cDr Jos\u00e9 Eleuterio Gonz\u00e1lez\u201d"},{"name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2020.04.017"},{"key":"e_1_3_3_4_2","first-page":"89","article-title":"Paclitaxel's mechanistic and clinical effects on breast cancer","volume":"9","author":"Abu Samaan TM","unstructured":"Abu Samaan TM, Samec M, Liskova A, et al. 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