{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:44:18Z","timestamp":1777934658091,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2025,10]]},"abstract":"\n Introduction<\/jats:title>\n The multikinase inhibitor midostaurin is the first targeted drug for the treatment of AML FLT3. It reduces mortality by 23% more than standard chemotherapy group. Although it has many gastrointestinal side effects, there is no data in the literature regarding its association with acute pancreatitis. We wanted to present an acute pancreatitis case that developed after midostaurin treatment in our clinic.<\/jats:p>\n <\/jats:sec>\n \n Case Report<\/jats:title>\n A patient with AML FLT3 who developed abdominal pain, elevated amylase-lipase enzymes and increased volume around the pancreas on abdominal imaging after the addition of midostaurin to chemotherapy was hospitalized with a prediagnosis of acute pancreatitis.<\/jats:p>\n <\/jats:sec>\n \n Management & Outcome<\/jats:title>\n Oral feeding was stopped, intravenous hydration was provided and anti-symptomatic treatment was given. The patient was discharged on the 4th day of hospitalization after the acute pancreatitis clinic resolved.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Drug induced acute pancreatitis is a rare clinical condition which is difficult to diagnose. It has a good prognosis and low mortality rate. The mechanisms of drug-induced pancreatitis include immunological reactions, direct toxic effect, accumulation of toxic metabolites, overstimulation of pancreatic acinar cells, ischemia, intravascular thrombosis and increased viscosity of pancreatic secretion. Although there are many gastrointestinal side effects of midostaurin, there are no clear data in the literature regarding the relationship with acute pancreatitis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10781552241304755","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T08:00:32Z","timestamp":1733385632000},"page":"835-838","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Midostaurin-Associated acute pancreatitis"],"prefix":"10.1177","volume":"31","author":[{"given":"Mert","family":"Akyildiz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nebi Cankat","family":"Geygel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esma Hazal","family":"Burhan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0026-2396","authenticated-orcid":false,"given":"Erdinc","family":"Gulumsek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Begum Seyda","family":"Avci","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin Ali","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih Necip","family":"Arici","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Bankir","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayyibe","family":"Saler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilmi Erdem","family":"Sumbul","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614359"},{"key":"e_1_3_2_4_2","first-page":"5113","article-title":"Oxaliplatin-induced pancreatitis: a case series","volume":"30","author":"Butt W","year":"2010","unstructured":"Butt W, Saadati H, Saif MW. Oxaliplatin-induced pancreatitis: a case series. Anticancer Res 2010; 30: 5113\u20135115.","journal-title":"Anticancer Res"},{"key":"e_1_3_2_5_2","first-page":"45","article-title":"Drug-induced acute pancreatitis: a review","volume":"15","author":"Jones MR","year":"2015","unstructured":"Jones MR, Hall OM, Kaye AM, et al. Drug-induced acute pancreatitis: a review. Ochsner J 2015; 15: 45\u201351.","journal-title":"Ochsner J"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.11.023"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-012-0245-9"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v5.i4.405"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552241304755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552241304755","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552241304755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:30:36Z","timestamp":1777689036000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552241304755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,5]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/10781552241304755"],"URL":"https:\/\/doi.org\/10.1177\/10781552241304755","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,5]]}}}