{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:44:47Z","timestamp":1777934687225,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Palliative care aims to improve the quality of life for patients with terminal illnesses by addressing physical, psychological, and social needs. However, only 14% of individuals globally who need palliative care receive it. In Pakistan, the availability is critically low, with a palliative care-to-population ratio of 1:90 million. Access to strong opioids for pain relief is severely restricted, with only 2% of terminally ill patients receiving adequate analgesia. These limitations, driven by concerns over opioid misuse and regulatory restrictions, highlight the urgent need for effective, accessible non-opioid alternatives. Suzetrigine, a novel NaV1.8 channel inhibitor, may offer a promising solution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This brief review summarizes clinical trial data from multiple Phase 2 and Phase 3 studies evaluating the efficacy and safety of Suzetrigine in managing acute and chronic pain. Primary endpoints included the time-weighted sum of pain intensity difference over 48 hours and weekly average pain score reductions assessed using the numeric pain rating scale. The implications of these findings were contextualized in the setting of Pakistan's opioid-restricted palliative care landscape.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Suzetrigine demonstrated statistically and clinically significant analgesic effects in trials involving postoperative pain, lumbar radiculopathy, and diabetic neuropathy. The drug was well-tolerated, with adverse events such as nausea, headache, and constipation being mild and infrequent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Suzetrigine presents a viable non-opioid analgesic alternative for palliative care in Pakistan, where regulatory and systemic barriers limit opioid access. Its introduction could enhance pain management, reduce opioid-related harms, and support the development of a safer, more accessible palliative care model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552251340330","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T03:23:50Z","timestamp":1749525830000},"page":"1188-1190","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Suzetrigine: A potential alternative for palliative pain management in Pakistan's opioid-restricted healthcare system"],"prefix":"10.1177","volume":"31","author":[{"given":"Mahmood","family":"Memon","sequence":"first","affiliation":[{"name":"Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Jinnah Sindh Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Parkash","sequence":"additional","affiliation":[{"name":"Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahek","family":"Bansari","sequence":"additional","affiliation":[{"name":"Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muaaz","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ayub Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anosh","family":"Khowaja","sequence":"additional","affiliation":[{"name":"Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahir","family":"Bansari","sequence":"additional","affiliation":[{"name":"Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farina Fatima","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayesha","family":"Naseer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayesha","family":"Almas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4589-7029","authenticated-orcid":false,"given":"Muhammad Momin","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2016.32"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.05.011"},{"key":"e_1_3_3_4_2","first-page":"1","article-title":"Palliative care in Pakistan: current landscape, challenges, progress and the way forward","author":"Ambreen A","unstructured":"Ambreen A, Taj A, Zaheer H, et al. Palliative care in Pakistan: current landscape, challenges, progress and the way forward. Int J Cancer Sci Ther 2023; 5: 1\u20135.","journal-title":"Int J Cancer Sci Ther"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2209870"},{"key":"e_1_3_3_6_2","unstructured":"Vertex Announces Results From Phase 2 Study of Suzetrigine for the Treatment of Painful Lumbosacral Radiculopathy [press release]. 2024."},{"key":"e_1_3_3_7_2","unstructured":"Vertex Announces Positive Results From Phase 2 Study of VX-548 for the Treatment of Painful Diabetic Peripheral Neuropathy [press release]. 2023."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02118-0"}],"updated-by":[{"DOI":"10.1177\/10781552251355823","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000}}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552251340330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552251340330","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552251340330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:31:09Z","timestamp":1777689069000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552251340330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":7,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1177\/10781552251340330"],"URL":"https:\/\/doi.org\/10.1177\/10781552251340330","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]}}}