{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:11:43Z","timestamp":1790331103665,"version":"4.1.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Numerous injectable anticancer drugs are administered at varying doses based on the body surface area and weight of the patients, often resulting in a certain volume of residual medication. Several anticancer drugs are expensive, thus, their increased use has led to a corresponding increase in drug waste and healthcare costs. Two potential solutions to this issue include drug vial optimization (DVO) and dose rounding (DR). However, DR has rarely been implemented in Japan. Here, we evaluated DVO and DR to assess whether DR could be a viable strategy to reduce the number of anticancer drugs discarded and minimize drug-related costs in Japan.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Patients who received bevacizumab, ramucirumab, gemcitabine, or levofolinate between January and December 2023 at Kanagawa Prefectural Ashigarakami Hospital (Ashigarakami) and Ogaki Municipal Hospital (Ogaki) were included in this study. Actual quantities used for each anticancer drug were extracted from electronic medical records, and the quantities used of drugs during the application of DVO and DR were calculated. Based on these findings, we estimated the reduction in drug waste and the associated cost savings for DVO and DR.\n                    <jats:bold>Results:<\/jats:bold>\n                    DR was more effective than DVO in minimizing the waste of drugs, with 0% waste for gemcitabine at Ogaki and 0% waste for levofolinate at both institutions.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Compared with DVO, DR is not influenced by the number of patients treated or the volume of anticancer drugs administered, making it feasible for implementation across a wide range of institutions and a highly effective strategy for minimizing waste. DR should be advocated as a key approach for reducing drug costs in Japan in the future.\n                  <\/jats:p>","DOI":"10.1177\/10781552251341567","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T19:19:22Z","timestamp":1747855162000},"page":"1352-1360","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of dose rounding and drug vial optimization for reducing anticancer drug waste"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4579-4565","authenticated-orcid":false,"given":"Tomohiko","family":"Harada","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Kanagawa Prefectural Ashigarakami Hospital, Ashigarakami-Gun, Kanagawa, Japan"},{"name":"Gifu Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3422-3072","authenticated-orcid":false,"given":"Eiseki","family":"Usami","sequence":"additional","affiliation":[{"name":"Ogaki Municipal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Aso","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kanagawa Prefectural Ashigarakami Hospital, Ashigarakami-Gun, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsumi","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kanagawa Prefectural Ashigarakami Hospital, Ashigarakami-Gun, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukari","family":"Imanishi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kanagawa Prefectural Ashigarakami Hospital, Ashigarakami-Gun, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kanagawa Prefectural Ashigarakami Hospital, Ashigarakami-Gun, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Moriya","sequence":"additional","affiliation":[{"name":"Ogaki Municipal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Asano","sequence":"additional","affiliation":[{"name":"Ogaki Municipal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6499-7060","authenticated-orcid":false,"given":"Makiko","family":"Go","sequence":"additional","affiliation":[{"name":"Ogaki Municipal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Kimura","sequence":"additional","affiliation":[{"name":"Ogaki Municipal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9110-9604","authenticated-orcid":false,"given":"Yoshihiro","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Gifu Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2486-8169","authenticated-orcid":false,"given":"Tomoaki","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Gifu Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"353","article-title":"Drug vial optimization (DVO) for anti-cancer drugs","volume":"44","author":"Iwamoto T","year":"2017","unstructured":"Iwamoto T. Drug vial optimization (DVO) for anti-cancer drugs. Gan To Kagaku Ryoho 2017; 44: 353\u2013356.","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-020-05822-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.936686"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2011.05.013"},{"key":"e_1_3_3_6_2","first-page":"743","article-title":"Economic loss of remaining contents in molecular target drug preparation and the simulation for cost saving","volume":"43","author":"Usami E","year":"2016","unstructured":"Usami E, Kimura M, Fukuoka T, et al. Economic loss of remaining contents in molecular target drug preparation and the simulation for cost saving. Gan To Kagaku Ryoho 2016; 43: 743\u2013747.","journal-title":"Gan To Kagaku Ryoho"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2017.025411"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/CCI.21.00024"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxab479"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/OP.23.00688"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1078155214533369"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp079"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/10781552231178675"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/10781552231203403"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552251341567","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552251341567","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552251341567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:56:14Z","timestamp":1790330174000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552251341567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/10781552251341567"],"URL":"https:\/\/doi.org\/10.1177\/10781552251341567","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,21]]}}}