{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:44:37Z","timestamp":1777934677932,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Lenalidomide is dispensed through a limited distribution network, leading to longer prescription fill times. Acquiring lenalidomide involves navigating the risk evaluation and mitigation strategies (REMS) program, insurance prior authorization, and financial assistance for out-of-pocket costs. Health disparities, including socioeconomic status, health literacy, language barriers, and geography, can further delay access. This study aimed to identify and analyze factors contributing to delays in access to lenalidomide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study used electronic health records within the Brown University Health system to identify adults newly diagnosed with hematologic malignancies between June 1, 2019 and June 1, 2024, with a lenalidomide prescription. A stepwise multiple linear regression evaluated factors affecting dispensation time. The primary endpoint was to identify factors contributing to delays in lenalidomide acquisition from a health equity perspective. The secondary endpoint was to determine the median time from prescription generation to dispensation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 328 patients with a mean age of 71 years; 53% were male and 80% were White. Comorbidities included cardiovascular disease (53%), diabetes (15%), obesity (21%), respiratory disease (8%), and chronic kidney disease (7%). Eighteen percent of patients required transportation assistance. The primary endpoint revealed 54% required financial assistance, which was associated with delayed lenalidomide dispensation (P\u2009&lt;\u20090.05). The secondary endpoint showed a median time of 8 days (IQR, 5\u201314) to dispense the prescription.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study found that lenalidomide prescriptions took a median of 8 days to fill, with those requiring financial assistance experiencing longer delays. These findings suggest that insurance processes and health disparities hinder timely access.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552251348222","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T04:02:02Z","timestamp":1749614522000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying health disparities in lenalidomide access"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6178-3560","authenticated-orcid":false,"given":"Ngan N.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Rhode Island Hospital, Brown University Health, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin P.","family":"Huynh","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital, Brown University Health, Providence, RI, USA"},{"name":"University of Rhode Island College of Pharmacy, Kingston, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna J.","family":"Wu","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital, Brown University Health, Providence, RI, USA"},{"name":"University of Rhode Island College of Pharmacy, Kingston, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah M.","family":"Kisla","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital, Brown University Health, Providence, RI, USA"},{"name":"University of Rhode Island College of Pharmacy, Kingston, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6231-8663","authenticated-orcid":false,"given":"Jamie N.","family":"Read","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital, Brown University Health, Providence, RI, USA"},{"name":"University of Rhode Island College of Pharmacy, Kingston, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1087-7468","authenticated-orcid":false,"given":"Annabel G.","family":"La","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital, Brown University Health, Providence, RI, USA"},{"name":"University of Rhode Island College of Pharmacy, Kingston, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darlene","family":"Tat","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital, Brown University Health, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9968-0349","authenticated-orcid":false,"given":"Britny R.","family":"Brown","sequence":"additional","affiliation":[{"name":"University of Rhode Island College of Pharmacy, Kingston, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/2040620718775629"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv102"},{"key":"e_1_3_2_4_2","unstructured":"Lin A. Challenges and Concerns Associated with Member Institution Access to Limited Distribution Medications https:\/\/www.nccn.org\/docs\/default-source\/clinical\/accessldmfinal_6-29-21-(002).pdf?sfvrsn=93e1fd95_0 (2021 accessed 10 November 2024)."},{"key":"e_1_3_2_5_2","volume-title":"Revlimid (package insert)","author":"Bristol-Myers Squibb Inc","year":"2023","unstructured":"Bristol-Myers Squibb Inc. Revlimid (package insert). New Jersey: Bristol-Myers Squibb Inc, 2023."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1078155218815283"},{"key":"e_1_3_2_7_2","first-page":"198","article-title":"Assessing the impact of limited distribution drug networks based on time to accessing oral oncolytic agents at an integrated specialty pharmacy","volume":"10","author":"Wyatt H","year":"2020","unstructured":"Wyatt H, Peter M, Zuckerman A, et al. Assessing the impact of limited distribution drug networks based on time to accessing oral oncolytic agents at an integrated specialty pharmacy. J Hematol Oncol Pharm 2020; 10: 198\u2013205.","journal-title":"J Hematol Oncol Pharm"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00642"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.19.00309"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-024-08619-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2023.08.008"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3735-1"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.09.618"},{"key":"e_1_3_2_14_2","article-title":"Provider and patient burdens of obtaining oral anticancer medications","volume":"24","author":"Geynisman D","year":"2018","unstructured":"Geynisman D, Meeker C, Doyle J, et al. Provider and patient burdens of obtaining oral anticancer medications. Am J Manag Care 2018; 24: e128\u2013e133.","journal-title":"Am J Manag Care"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552251348222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552251348222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552251348222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:31:16Z","timestamp":1777689076000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552251348222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,11]]},"references-count":13,"alternative-id":["10.1177\/10781552251348222"],"URL":"https:\/\/doi.org\/10.1177\/10781552251348222","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,11]]},"article-number":"10781552251348222"}}