{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:45:21Z","timestamp":1777934721418,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Laryngopharyngeal dysesthesia is considered an acute peripheral neuropathy secondary to oxaliplatin neurotoxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>We report a case of laryngopharyngeal dysesthesia that developed in a patient with colon adenocarcinoma after receiving her third cycle of oxaliplatin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management &amp; outcome<\/jats:title>\n                    <jats:p>She was treated with antihistamines, steroids, oxygen, and adrenaline and referred to the allergy department for investigation of a hypersensitivity reaction to the drug. Skin tests and tryptase extracted after the acute episode ruled out this possibility. However, the patient presented a slight elevation of interleukin 6, commonly observed in cytokine release reactions. The patient continued her oxaliplatin treatment with cautious administration and under the supervision of the allergist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Laryngopharyngeal dysesthesia is part of oxaliplatin neurotoxicity and does not require discontinuation of the drug. However, in patients with severe laryngopharyngeal dysesthesia symptoms, it would be advisable to perform a differential diagnosis with hypersensitivity reactions and cytokine release reactions, whose management differs from neurotoxic reactions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552251358672","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T08:19:26Z","timestamp":1752567566000},"page":"1358-1362","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Laryngopharyngeal dysesthesia as a possible clinical manifestation of a cytokine release reaction due to oxaliplatin"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1859-143X","authenticated-orcid":false,"given":"Maria Cruz","family":"Torres Gorriz","sequence":"first","affiliation":[{"name":"Allergy Department, Castellon University General Hospital, Castell\u00f3n, Spain"},{"name":"Doctoral School, Jaume I University, Castellon de la Plana, Spain"},{"name":"FISABIO Foundation Research Group, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli\u00e1n","family":"Borras Cuartero","sequence":"additional","affiliation":[{"name":"Allergy Department, Castellon Provincial Hospital Consortium, Castell\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Viedma Ayll\u00f3n","sequence":"additional","affiliation":[{"name":"Allergy Department, Castellon University General Hospital, Castell\u00f3n, Spain"},{"name":"FISABIO Foundation Research Group, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Molina Saera","sequence":"additional","affiliation":[{"name":"Medical Oncology Departament, Castellon Provincial Hospital Consortium, Castell\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Enrique","sequence":"additional","affiliation":[{"name":"Allergy Department, Castellon University General Hospital, Castell\u00f3n, Spain"},{"name":"Doctoral School, Jaume I University, Castellon de la Plana, Spain"},{"name":"FISABIO Foundation Research Group, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/10781552241255289"},{"key":"e_1_3_2_3_2","first-page":"843019","article-title":"Neurotoxicity caused by the treatment with platinum analogues","author":"Amptoulach S","year":"2011","unstructured":"Amptoulach S, Tsavaris N. Neurotoxicity caused by the treatment with platinum analogues. Chemother Res Pract 2011: 843019. doi: https:\/\/doi.org\/10.1155\/2011\/843019. Epub 2011 Jun 27. PMID: 22312559; PMCID: PMC3265255.","journal-title":"Chemother Res Pract"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2002.35524"},{"key":"e_1_3_2_5_2","first-page":"331","article-title":"Differentiating between laryngopharyngeal dysesthesia and hypersensitivity reactions to oxaliplatin and addressing dyspnea: 2 case reports","volume":"16","author":"Kawaguchi F","year":"2023","unstructured":"Kawaguchi F, Aoyama T, Tsuneki T, et al. Differentiating between laryngopharyngeal dysesthesia and hypersensitivity reactions to oxaliplatin and addressing dyspnea: 2 case reports. Case Rep Oncol 2023; 16: 331\u2013337. PMID: 37187686; PMCID: PMC10176188.","journal-title":"Case Rep Oncol"},{"issue":"4","key":"e_1_3_2_6_2","article-title":"Management of infusion reactions to systemic anticancer therapy: ESMO ClinicaPractice guidelines","volume":"28","author":"Rosell\u00f3 S","year":"2017","unstructured":"Rosell\u00f3 S, Blasco I, Garc\u00eda Fabregat L, et al. Management of infusion reactions to systemic anticancer therapy: ESMO ClinicaPractice guidelines. Ann Oncol 2017; 28(suppl_4): iv100\u2013iv118. Erratum in: Ann Oncol. 2018 Oct 1;29(Suppl 4):iv260. doi: 10.1093\/annonc\/mdy158. PMID: 28881914.","journal-title":"Ann Oncol"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2002.35525"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00667-1"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-7563.2011.01515.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200411000-00010"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/10781552221077038"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27732"},{"key":"e_1_3_2_14_2","first-page":"105","article-title":"Oxaliplatin may induce cytokine-release syndrome in colorectal cancer patients","volume":"16","author":"Tonini G","year":"2002","unstructured":"Tonini G, Santini D, Vincenzi B, et al. Oxaliplatin may induce cytokine-release syndrome in colorectal cancer patients. J Biol Regul Homeost Agents 2002; 16: 105\u2013109. PMID: 12144121.","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14644"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.15113"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2024.1479469"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2022.100640"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0343-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.02.013"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1471038"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552251358672","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552251358672","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552251358672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:31:28Z","timestamp":1777689088000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552251358672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1177\/10781552251358672"],"URL":"https:\/\/doi.org\/10.1177\/10781552251358672","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]}}}