{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:53:23Z","timestamp":1789502003615,"version":"build-2803163510"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Clinical Research Special Funding of Wu Jie-ping Medical Foundation","award":["320.6750.2023-06-33"],"award-info":[{"award-number":["320.6750.2023-06-33"]}]},{"name":"the Research Project of Xiangnan University","award":["2022JX151"],"award-info":[{"award-number":["2022JX151"]}]},{"name":"the Research Project of Xiangnan University","award":["2022JX166"],"award-info":[{"award-number":["2022JX166"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Limited data on the effect of hematologic disorders on the busulfan (Bu) pharmacokinetics in children undergoing allogeneic hematopoietic stem cell transplantation (HSCT) is available to date. This study aimed to investigate pharmacokinetic characteristics after the first Bu infusion in children with different hematologic disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 172 Bu concentrations from 43 patients with HSCT and their demographics and characteristics were included to investigate the correlations between different hematologic disorders and Bu concentration or area under the concentration time curve (AUC) using univariate and multivariate regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bu concentration and AUC after the first dose were significantly higher in patients with leukemia than in patients with non-malignant hematologic disorders (NMHD) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). A high variability was observed with 14 (53.8%) of Bu AUC lower than 900\u2005\u00b5M\u2009\u00d7\u2009min (3.69\u2005mg\u2009\u00d7\u2009h\/L) in patients with NMHD and 15 (88.2%) of Bu AUC higher than 1350\u2005\u00b5M\u2009\u00d7\u2009min (5.54\u2005mg\u2009\u00d7\u2009h\/L) in patients with leukemia. In univariate analysis, concomitant use of glucocorticoids affected Bu AUC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The Bu AUC was significantly correlated with alanine transaminase (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.004), total bile acids (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.003) and total bilirubin (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, hematologic disorders was the only independent influencing factor of Bu AUC variation, after adjusting for the above variables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Variability in Bu AUC was related to hematologic disorders of children with HSCT, which requires therapeutic drug monitoring and dose adjustment. Different phenotypes of patients should be considered when developing individualized Bu dosing regimen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552261424402","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:43:41Z","timestamp":1775040221000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Variability of busulfan area under the concentration-time curve in children with different hematologic disorders"],"prefix":"10.1177","author":[{"given":"Jie","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The First People's Hospital of Chenzhou, Xiangnan University, Chenzhou, China"},{"name":"Department of Pharmacology, Xiangnan University, Chenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First People's Hospital of Chenzhou, Xiangnan University, Chenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, The First People's Hospital of Chenzhou, Xiangnan University, Chenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First People's Hospital of Chenzhou, Xiangnan University, Chenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First People's Hospital of Chenzhou, Xiangnan University, Chenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First People's Hospital of Chenzhou, Xiangnan University, Chenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anfa","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First People's Hospital of Chenzhou, Xiangnan University, Chenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First People's Hospital of Chenzhou, Xiangnan University, Chenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6844-3949","authenticated-orcid":false,"given":"Guangting","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First People's Hospital of Chenzhou, Xiangnan University, Chenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0564-x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-020-00947-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01545-x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02028-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2023.2192924"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.08.014"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-023-02166-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e318039b478"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65919-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000002106"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1413485"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27006"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-024-01397-w"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.07.013"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3182a04fc7"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000131"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-265405"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14202"}],"container-title":["Journal 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