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The search strategy combined medical subject headings related to \u0441ardio-oncology, antineoplastic agents, cardioprotective strategies. Reference lists of included studies were manually searched for relevant publications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Summary<\/jats:title>\n                    <jats:p>The review identifies distinct molecular pathways of cardiotoxicity, ranging from oxidative stress and Top2\u03b2 inhibition in anthracyclines to immune-mediated myocarditis with checkpoint inhibitors and direct fibrotic damage from radiation. Results for standard heart failure medications remain controversial, often demonstrating no protective benefit in large-scale trials. While baseline risk stratification using biomarkers and advanced imaging methods is essential, current pharmacological interventions show significant heterogeneity in efficacy. Emerging non-pharmacological strategies, particularly structured aerobic exercise and lifestyle modification, show promise in mitigating systemic inflammation and preserving cardiac reserve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The existing arsenal of methods for the prevention and treatment of CTRCD\/CTR-CVT remains very limited and does not meet the scale of the problem. Future progress in cardio-oncology depends on the implementation of multidisciplinary support for oncological patients and the development of personalized, dynamic cardio-risk assessment tools integrated with artificial intelligence with innovative cardioprotectors. There is an urgent need to intensify fundamental and clinical research aimed at developing innovative cardioprotective agents and personalized approaches to the management of cancer patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552261437385","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T05:43:53Z","timestamp":1774849433000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardioprotection in oncology: Mechanisms, risks and therapeutic strategies"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4374-6422","authenticated-orcid":false,"given":"E.","family":"Plotnikov","sequence":"first","affiliation":[{"name":"Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University"},{"name":"Pharmaceutical Analysis Department, Siberian State Medical University, Tomsk, Moskovsky Trakt, Russia"},{"name":"Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-7916","authenticated-orcid":false,"given":"V.","family":"Chernov","sequence":"additional","affiliation":[{"name":"Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University"},{"name":"Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4568-1781","authenticated-orcid":false,"given":"R.","family":"Zelchan","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1176-2441","authenticated-orcid":false,"given":"M.","family":"Larkina","sequence":"additional","affiliation":[{"name":"Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University"},{"name":"Pharmaceutical Analysis Department, Siberian State Medical University, Tomsk, Moskovsky Trakt, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7543-9611","authenticated-orcid":false,"given":"A.","family":"Artamonov","sequence":"additional","affiliation":[{"name":"Federal Research & Clinic Center of Space Medicine and Biology of the Federal Biomedical Agency"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2153-7945","authenticated-orcid":false,"given":"M.","family":"Belousov","sequence":"additional","affiliation":[{"name":"Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University"},{"name":"Pharmaceutical Analysis Department, Siberian State Medical University, Tomsk, Moskovsky Trakt, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/11795549241298541"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003231"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/antib12040072"},{"key":"e_1_3_2_5_2","first-page":"66","article-title":"Trends in stereotactic radiosurgery for meningioma: the top 100 most cited articles","volume":"1","author":"Al Habsi T","year":"2024","unstructured":"Al Habsi T, Alibrahim H, Al Manthari U, et al. 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