{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:02:39Z","timestamp":1788991359692,"version":"build-2803163510"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trastuzumab deruxtecan (T-DXd) is an effective HER2-directed antibody\u2013drug conjugate used across multiple solid tumors. Interstitial lung disease (ILD) and pneumonitis are well-recognized as clinically significant toxicities associated with T-DXd. However, most real-world studies have focused on signal detection rather than the clinical context in which ILD is reported. The patterns by which ILD co-occurs with other respiratory adverse events in routine clinical practice remain poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed adverse event reports submitted to the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) between 2015 and 2025 in which T-DXd was listed as a suspect drug. ILD, pneumonitis, and respiratory adverse events were identified using MedDRA Preferred Terms. A binary case\u2013event matrix was constructed, and hierarchical clustering was used to explore patterns of respiratory adverse event co-reporting. Subgroup analyses were conducted for breast, gastric\/gastroesophageal junction (GEJ), and lung cancer. Cluster stability was assessed using bootstrap resampling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 759 ILD cases and 289 pneumonitis cases associated with T-DXd were identified. In breast cancer reports, ILD consistently clustered with dyspnea and cough, forming a concentrated respiratory co-reporting phenotype. In gastric\/GEJ cancer reports, ILD showed strong co-reporting with pneumonia, suggesting overlap between drug-related lung injury and infectious respiratory presentations. Lung cancer reports demonstrated more heterogeneous respiratory co-reporting patterns, with less consistent clustering of ILD with specific symptoms. Network analysis identified ILD as a central node within the respiratory adverse event network. Across all tumor types, respiratory clusters were reproducible in bootstrap analyses, indicating stable and non-random co-reporting structures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ILD associated with T-DXd is reported alongside distinct respiratory adverse event patterns that differ across tumor types. Examining these co-reported respiratory events may help clinicians better interpret ILD reports in real-world practice, particularly in the setting of overlapping or non-specific pulmonary symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552261442891","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T13:11:52Z","timestamp":1776345112000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Co-reported respiratory adverse events in trastuzumab deruxtecan\u2013associated interstitial lung disease: A pharmacovigilance analysis of the FAERS database"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6594-1712","authenticated-orcid":false,"given":"Seda","family":"Jeral Evin\u00e7","sequence":"first","affiliation":[{"name":"Istanbul University-Cerrahpa\u015fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7a\u011fla","family":"Ey\u00fcpler Akmercan","sequence":"additional","affiliation":[{"name":"G\u00f6ztepe Prof. Dr S\u00fcleyman Yal\u00e7\u0131n City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeliha","family":"Birsin","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpa\u015fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selin","family":"Cebeci","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpa\u015fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emir","family":"\u00c7erme","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpa\u015fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vali","family":"Aliyev","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpa\u015fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Abbasov","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpa\u015fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"\u00c7i\u00e7ek","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpa\u015fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcheyla","family":"Atak","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpa\u015fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nebi Serkan","family":"Demirci","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpa\u015fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zkan","family":"Alan","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpa\u015fa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1914510"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2004413"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00064-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2022.102378"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S508773"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/17534666241299935"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000079633"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32100575"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100404"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/OP.22.00480"},{"key":"e_1_3_2_12_2","first-page":"314","article-title":"Statistical and graphical approaches for disproportionality analysis of spontaneously-reported adverse events in pharmacovigilance","volume":"11","author":"Zink RC","year":"2013","unstructured":"Zink RC, Huang Q, Zhang LY, et al. Statistical and graphical approaches for disproportionality analysis of spontaneously-reported adverse events in pharmacovigilance. Chin J Nat Med 2013; 11: 314\u2013320.","journal-title":"Chin J Nat Med"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.50"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/10781552251356906"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2112431"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552261442891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552261442891","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552261442891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:32:41Z","timestamp":1777689161000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552261442891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":14,"alternative-id":["10.1177\/10781552261442891"],"URL":"https:\/\/doi.org\/10.1177\/10781552261442891","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"article-number":"10781552261442891"}}