{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T17:01:38Z","timestamp":1784998898958,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia and Minist\u00e9rio da Educa\u00e7\u00e3o, Ci\u00eancia e Inova\u00e7\u00e3o","award":["UID\/50006\/2025 DOI 10.54499\/UID\/50006\/2025"],"award-info":[{"award-number":["UID\/50006\/2025 DOI 10.54499\/UID\/50006\/2025"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gravimetric control is an objective quality assurance strategy for detecting compounding errors in antineoplastic preparations. However, implementation remains inconsistent across hospital pharmacies, particularly in resource-limited settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop, and preliminarily assess the feasibility, in a pilot study, of an in-house gravimetric control system for routine quality control of antineoplastic preparations in a hospital chemotherapy compounding unit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A descriptive cross-sectional observational study was conducted in a Portuguese hospital between February and March 2024. Antineoplastic preparations compounded in syringes, infusion bags, or pumps were included. Drug densities were determined experimentally using a semi-analytical precision scale. Syringe dead-space-correction was calculated where applicable. A semi-automated Microsoft Excel\n                      <jats:sup>\u00ae<\/jats:sup>\n                      -based gravimetric control system was developed to calculate expected mass and percentage deviation between expected and measured mass. Deviations \u22645% were considered acceptable. Method applicability was assessed in 47 preparations from 11 different drugs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Density coefficients of variation were consistently low across drugs and container types, supporting measurement precision and solution homogeneity. Differences between measured and dead-space-corrected densities were minimal (mean difference 0.006\u2005g\/mL; SD 0.004), indicating negligible practical impact. During applicability testing (n\u2009=\u200947), percentage errors ranged from 0.04% to 2.31%, all within the predefined \u00b15% acceptance threshold. No preparation required rejection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In this pilot study, the developed gravimetric control system proved to be practical, affordable, and reliable for routine quality control of chemotherapy preparations. The Excel\n                      <jats:sup>\u00ae<\/jats:sup>\n                      -based gravimetric control system allows rapid implementation without specialized software and may support standardization of compounding verification processes across hospital pharmacies. Wider inter-institutional validation is warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552261470007","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T14:05:13Z","timestamp":1784729113000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and feasibility assessment of an in-house gravimetric control system for quality assurance of antineoplastic compounding"],"prefix":"10.1177","author":[{"given":"D\u00e9bora","family":"Fonseca","sequence":"first","affiliation":[{"name":"Escola Superior de Sa\u00fade, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 4200-072 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"R\u00e9","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade da Regi\u00e3o de Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Pedro","family":"Cruz","sequence":"additional","affiliation":[{"name":"Unidade Local de Sa\u00fade da Regi\u00e3o de Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Isabel","family":"Oliveira","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Escola Superior de Sa\u00fade, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 4200-072 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3452-1459","authenticated-orcid":false,"given":"Fernando","family":"Moreira","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Escola Superior de Sa\u00fade, Instituto Polit\u00e9cnico do Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida, 4200-072 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2023-0513"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"ISOPP Standards for the safe handling of cytotoxics. 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