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Transitioning from traditional manual workflows to fully automated production offers multiple benefits: decreased pharmacy staff workload, reduced risk of repetitive strain injuries, minimized medication errors, and lower risk of occupational exposure to hazardous medicinal products, especially when the robotic preparation areas are fully enclosed. Several elements can facilitate efficient implementation and improve productivity and safety in the use of robotic systems. The purpose of this study was to aggregate insights from an international expert group of early adopters on optimizing both productivity and safety in robotic drug preparation. Eight best practices regarding workflow, quality management, software integration, cleaning protocols, staff training, and safety measures during drug shortages have been identified and agreed upon. 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