{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T17:01:08Z","timestamp":1785085268021,"version":"3.55.0"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"abstract":"\n Introduction<\/jats:title>\n Acute pancreatitis is a potential but rare adverse drug reaction. We report a delayed-onset case induced by daratumumab during multiple myeloma maintenance.<\/jats:p>\n <\/jats:sec>\n \n Case Report<\/jats:title>\n A 60-year-old non-smoking male under maintenance therapy with daratumumab, lenalidomide, and dexamethasone presented with sudden-onset acute abdominal pain and severe enzymatic elevation (amylase >40x ULN). Biliary and metabolic etiologies, as well as lenalidomide triggers, were thoroughly ruled out.<\/jats:p>\n <\/jats:sec>\n \n Management & Outcome<\/jats:title>\n Discontinuation of daratumumab and conservative management led to complete clinical and biochemical recovery. A Naranjo algorithm score of 5 indicated a probable causal relationship.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n CD38 inhibition may alter intracellular calcium homeostasis in pancreatic tissue, prompting long-term proactive pharmacovigilance in onco-hematology units even during late maintenance phases.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10781552261471787","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:36:36Z","timestamp":1784810196000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute pancreatitis induced by Daratumumab during multiple myeloma maintenance"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3326-7708","authenticated-orcid":false,"given":"Abel","family":"Trujillano Ruiz","sequence":"first","affiliation":[{"name":"Hospital Universitario de La L\u00ednea de la Concepci\u00f3n"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda de los Remedios","family":"Arcas Vega","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La L\u00ednea de la Concepci\u00f3n"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Sebasti\u00e1n","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La L\u00ednea de la Concepci\u00f3n"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Mar","family":"Romero Gonzalez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de La L\u00ednea de la Concepci\u00f3n"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i22.2902"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231883"},{"key":"e_1_3_2_4_2","unstructured":"Agencia Europea de Medicamentos. Ficha T\u00e9cnica o Resumen de las Caracter\u00edsticas del Producto: DARZALEX (daratumumab). Anexo I. Disponible en: https:\/\/www.ema.europa.eu."},{"key":"e_1_3_2_5_2","first-page":"77","article-title":"Bortezomib-induced acute pancreatitis, an uncommon adverse event","volume":"113","author":"Junquera Alonso E","year":"2021","unstructured":"Junquera Alonso E, Seoane Blanco L, Cano Calderero FX. Bortezomib-induced acute pancreatitis, an uncommon adverse event. Rev Esp Enferm Dig 2021; 113: 77.","journal-title":"Rev Esp Enferm Dig"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_3_2_7_2","first-page":"1","article-title":"Efficacy and safety of daratumumab in the treatment of multiple myeloma: a systematic review and meta-analysis","volume":"49","author":"Wang Y","year":"2021","unstructured":"Wang Y, Li Y, Chai Y. Efficacy and safety of daratumumab in the treatment of multiple myeloma: a systematic review and meta-analysis. J Int Med Res 2021; 49: 1\u201312.","journal-title":"J Int Med Res"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00940"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12112627"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/JP9.0000000000000168"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552261471787","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552261471787","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552261471787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:54:28Z","timestamp":1785084868000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552261471787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,23]]},"references-count":9,"alternative-id":["10.1177\/10781552261471787"],"URL":"https:\/\/doi.org\/10.1177\/10781552261471787","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,23]]},"article-number":"10781552261471787"}}