{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:26:52Z","timestamp":1786796812977,"version":"build-2736575974"},"reference-count":9,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>5-Fluorouracil (5-FU) is an antimetabolite widely used in colorectal, gastric, breast, and other solid tumors. Hypersensitivity reactions are uncommon but may be severe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>We report a 63-year-old woman with metastatic sigmoid colon cancer who developed an anaphylactic reaction during the second course of a 5-FU\u2014containing regimen, specifically following the bolus infusion. Skin prick and intradermal tests performed four weeks later were negative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management &amp; Outcome<\/jats:title>\n                    <jats:p>As no equally efficacious alternative existed within the planned regimen, rapid intravenous desensitization was performed using a 16-step protocol with four dilution solutions. Desensitization was completed without adverse events, and the subsequent 48-h continuous 5-FU infusion was also well tolerated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case adds to the limited literature on 5-FU desensitization and underscores its feasibility and safety in agent-dependent patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552261478571","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:45:21Z","timestamp":1786560321000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful rapid desensitization with 5-fluorouracil in a patient with metastatic sigmoid colon cancer: A case report"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9662-574X","authenticated-orcid":false,"given":"Aysu","family":"Okumu\u015f G\u00fc\u00e7l\u00fc","sequence":"first","affiliation":[{"name":"\u0130zmir City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orbay Tutku","family":"Seren","sequence":"additional","affiliation":[{"name":"\u0130zmir City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bar\u0131\u015f","family":"Gezici","sequence":"additional","affiliation":[{"name":"\u0130zmir City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papatya","family":"Bayrak De\u011firmenci","sequence":"additional","affiliation":[{"name":"\u0130zmir City Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058285"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860815)58:4<862::AID-CNCR2820580410>3.0.CO;2-3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2500\/108854199778553064"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40800-017-0068-6"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad072"},{"key":"e_1_3_3_7_2","first-page":"339","article-title":"Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion","volume":"11","author":"\u00c7akmak ME","year":"2024","unstructured":"\u00c7akmak ME, Oztop N, Ye\u011fit OO. Successful desensitization with 5-fluorouracil in a patient who developed anaphylaxis after 5-fluorouracil infusion. Alergol Pol - Niger J Allergol 2024; 11: 339\u2013341.","journal-title":"Alergol Pol - Niger J Allergol"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2025.01.021"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40521-015-0060-2"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198916040-00002"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552261478571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10781552261478571","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10781552261478571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T11:54:48Z","timestamp":1786794888000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10781552261478571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":9,"alternative-id":["10.1177\/10781552261478571"],"URL":"https:\/\/doi.org\/10.1177\/10781552261478571","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"article-number":"10781552261478571"}}