{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:09:47Z","timestamp":1789063787652,"version":"build-2803163510"},"reference-count":55,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To review the challenges associated with oral anticancer drug administration in older adults, focusing on dysphagia, dosage-form manipulation, medication-related risks, acceptability, and oncology-specific safety considerations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>A narrative literature review was conducted using PubMed, Scopus and ScienceDirect. Publications from January 2000 to March 2026 were identified using keywords related to geriatric oncology, dysphagia, oral dosage forms, dosage-form manipulation, oral anticancer agents, medication safety, acceptability, and hazardous drugs. Review articles, original studies, professional recommendations and regulatory documents were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Summary<\/jats:title>\n                    <jats:p>Swallowing disorders are common among older adults with cancer and may compromise oral anticancer therapy administration. Dosage-form manipulation practices, including tablet crushing and capsule opening, are frequently used despite their potential effects on drug stability, bioavailability, pharmacokinetics, and therapeutic efficacy. These concerns are amplified by the narrow therapeutic index of many oral anticancer agents and the risk of occupational, caregiver, and environmental exposure to hazardous drugs. Available evidence reveals gaps in standardized administration procedures and limited data supporting alternative administration strategies. A review of selected oral anticancer agents showed substantial variability in formulation constraints, manipulation practices, and supporting evidence. Emerging approaches, including dispersible and orodispersible formulations, multiparticulate systems, mini-tablets, and three-dimensional (3D) printed medicines, may improve treatment acceptability and reduce inappropriate dosage-form manipulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dysphagia and dosage-form manipulation remain underrecognized challenges in geriatric oncology, with implications for treatment safety, efficacy, adherence, and hazardous-drug exposure. Addressing these issues requires multidisciplinary collaboration, standardized procedures, patient-centered formulation design, and further research to support evidence-based practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552261486723","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:20:07Z","timestamp":1788841207000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral anticancer drug administration in older adults: A review of galenic challenges, medication-related risks, and future pharmaceutical perspectives"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6960-7947","authenticated-orcid":false,"given":"Sara","family":"Hajjaj","sequence":"first","affiliation":[{"name":"Sidi Mohamed Ben Abdellah University"},{"name":"Hassan II University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Cherif Chefchaouni","sequence":"additional","affiliation":[{"name":"Sidi Mohamed Ben Abdellah University"},{"name":"Hassan II University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9292-5864","authenticated-orcid":false,"given":"Safae","family":"Alaoui","sequence":"additional","affiliation":[{"name":"Sidi Mohamed Ben Abdellah University"},{"name":"Hassan II University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8889-7607","authenticated-orcid":false,"given":"Seham","family":"El Deeb","sequence":"additional","affiliation":[{"name":"Sidi Mohamed Ben Abdellah University"},{"name":"Hassan II University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soufiane","family":"El Marrakchi","sequence":"additional","affiliation":[{"name":"Sidi Mohamed Ben Abdellah University"},{"name":"Hassan II University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badreddine","family":"Moukafih","sequence":"additional","affiliation":[{"name":"Sidi Mohamed Ben Abdellah University"},{"name":"Hassan II University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima-Zahra","family":"Bandadi","sequence":"additional","affiliation":[{"name":"Sidi Mohamed Ben Abdellah University"},{"name":"Hassan II University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younes","family":"Rahali","sequence":"additional","affiliation":[{"name":"Mohammed V University, Faculty of Medicine And Pharmacy, Rabat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdeslam","family":"El Kartouti","sequence":"additional","affiliation":[{"name":"Sidi Mohamed Ben Abdellah University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Bennani","sequence":"additional","affiliation":[{"name":"Sidi Mohamed Ben Abdellah University"},{"name":"Hassan II University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.0319"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.6125"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.10.6559"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-025-01901-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2018.063"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/10781552211037976"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-019-1337-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-023-01056-y"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy11050167"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-013-0090-2"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2010.000068"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","unstructured":"ISOPP Standards for the safe handling of cytotoxics. 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