{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:52:04Z","timestamp":1792068724985,"version":"4.4.0"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ensuring the safety and quality of cytotoxic drug preparation is a core component of oncology pharmacy practice. In emerging settings, structured audit tools are essential to assess practices and support continuous quality improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop a standardized audit tool for assessing compliance with current standards for hospital cytotoxic drug preparation and to apply it in a specialized oncology hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A working group developed a structured audit tool based on 2023 Good Preparation Practices and international recommendations. The tool included domains, subdomains, and explicit compliance criteria. A 15-day audit was conducted using direct observation, document review, and staff interviews. Deviations were classified by criticality. Data were analyzed quantitatively using a standardized Excel-based framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 913 criteria were included in the audit tool, of which 289 were deemed not applicable at the hospital level. Consequently, 624 criteria were assessed across seven thematic areas. The overall compliance rate was 70%. Among the evaluated criteria, 23% were non-compliant and 7% were partially compliant. Among the non-compliant criteria, 27.4% were associated with a potential risk of adverse events. The proposed improvement actions were categorized into short-term and long-term measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides a structured audit framework for evaluating compliance with current Good Preparation Practices in hospital cytotoxic drug preparation. Its application highlighted priority areas for improving the quality and safety of preparation practices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552261495130","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:35:00Z","timestamp":1791815700000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and implementation of a standardized audit tool for cytotoxic drug preparation practices in oncology"],"prefix":"10.1177","author":[{"given":"Khalil","family":"Kallala","sequence":"first","affiliation":[{"name":"National Bone Marrow Transplant Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1316-1417","authenticated-orcid":false,"given":"Yosr","family":"Trabelsi","sequence":"additional","affiliation":[{"name":"National Bone Marrow Transplant Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-557X","authenticated-orcid":false,"given":"Ikram","family":"Fazaa","sequence":"additional","affiliation":[{"name":"National Bone Marrow Transplant Center"},{"name":"Laboratory of Chemical, Pharmaceutical and Pharmacological Drug Development LR12ES09, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Kamergi","sequence":"additional","affiliation":[{"name":"National Bone Marrow Transplant Center"},{"name":"University of Tunis Manar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibtihel","family":"Ellouze","sequence":"additional","affiliation":[{"name":"Military hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chema","family":"Drira","sequence":"additional","affiliation":[{"name":"National Bone Marrow Transplant Center"},{"name":"Laboratory of Chemical, Pharmaceutical and Pharmacological Drug Development LR12ES09, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0386-0200","authenticated-orcid":false,"given":"Leila","family":"Achour","sequence":"additional","affiliation":[{"name":"National Bone Marrow Transplant Center"},{"name":"Laboratory of Chemical, Pharmaceutical and Pharmacological Drug Development LR12ES09, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4509(06)75288-9"},{"key":"e_1_3_3_3_2","first-page":"190","article-title":"Cytotoxic drug dispersal, cytotoxic safety, and cytotoxic waste management: practices and proposed India-specific guidelines","volume":"38","author":"Capoor MR","year":"2017","unstructured":"Capoor MR, Bhowmik KT. Cytotoxic drug dispersal, cytotoxic safety, and cytotoxic waste management: practices and proposed India-specific guidelines. Indian J Med Paediatr Oncol 2017; 38: 190\u2013197.","journal-title":"Indian J Med Paediatr Oncol"},{"key":"e_1_3_3_4_2","unstructured":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des produits de sant\u00e9. Bonnes pratiques de pr\u00e9paration. Saint-Denis: ANSM; 2023."},{"key":"e_1_3_3_5_2","first-page":"202","article-title":"Managing infection in cancer patients and other immunocompromised children","volume":"12","author":"Steele RW.","year":"2012","unstructured":"Steele RW. Managing infection in cancer patients and other immunocompromised children. Ochsner J 2012; 12: 202\u2013210.","journal-title":"Ochsner J"},{"key":"e_1_3_3_6_2","volume-title":"Septic\u00e9mie et choc infectieux","author":"Forrester JD.","year":"2023","unstructured":"Forrester JD. Septic\u00e9mie et choc infectieux. 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