{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:46:05Z","timestamp":1791834365808,"version":"4.3.4"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Environmental monitoring of antineoplastic drug contamination has primarily focused on medication preparation areas and frequently touched surfaces. Consequently, contamination in nonpreparation areas and on infrequently touched surfaces, such as ceilings, remains poorly characterized. This study evaluated fluorouracil contamination on floors and ceilings in preparation and nonpreparation areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was conducted at Aichi Cancer Center, Japan. Samples were collected from floor and ceiling surfaces in the hospital pharmacy, outpatient chemotherapy center, and inpatient ward. Cleaning practices at the sampling sites were also assessed. Fluorouracil concentrations were measured using liquid chromatography\u2013tandem mass spectrometry. At the time of sampling, closed-system drug-transfer devices (CSTDs) were not used for fluorouracil preparation or administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fluorouracil was detected on all sampled floor and ceiling surfaces, including those in nonpreparation areas where antineoplastic drugs were not handled. The highest contamination levels were detected on the preparation room floor (3.104\u2005ng\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ) and the pharmacy break room ceiling (2.440\u2005ng\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ). In the outpatient chemotherapy center, relatively high contamination levels were detected on the nursing station floor (0.622\u2005ng\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ) and nursing break room ceiling (0.419\u2005ng\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fluorouracil contamination was detected in nonpreparation areas and on ceiling surfaces near air-conditioning units that were not routinely touched or cleaned. These findings suggest that contamination may spread through the movement of healthcare workers and materials and may accumulate on infrequently cleaned surfaces. As part of contamination control, the use of CSTDs may need to be implemented and environmental monitoring may need to be extended beyond medication preparation areas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10781552261495860","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:03:27Z","timestamp":1791551007000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Environmental contamination with fluorouracil on floors and ceilings in antineoplastic drug preparation and nonpreparation areas of a Japanese cancer center"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2318-2867","authenticated-orcid":false,"given":"Koh","family":"Yoshida","sequence":"first","affiliation":[{"name":"Aichi Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0709-3911","authenticated-orcid":false,"given":"Akimitsu","family":"Maeda","sequence":"additional","affiliation":[{"name":"Aichi Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Asano","sequence":"additional","affiliation":[{"name":"Aichi Children's Health and Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3330-7155","authenticated-orcid":false,"given":"Naoya","family":"Tomiyasu","sequence":"additional","affiliation":[{"name":"Aichi Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Iida","sequence":"additional","affiliation":[{"name":"Aichi Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyoko","family":"Takahata","sequence":"additional","affiliation":[{"name":"Aichi Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosaku","family":"Uchida","sequence":"additional","affiliation":[{"name":"Aichi Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.56.6.354"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e3181f73ae6"},{"key":"e_1_3_3_4_2","article-title":"The meta-analysis of sister chromatid exchange as a biomarker in healthcare workers with occupational exposure to antineoplastic drugs","volume":"102","author":"Hu J","year":"2023","unstructured":"Hu J, Zhao F, Liu L, et al. The meta-analysis of sister chromatid exchange as a biomarker in healthcare workers with occupational exposure to antineoplastic drugs. Medicine (Baltimore) 2023; 102: e34781.","journal-title":"Medicine (Baltimore)"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/nop2.1853"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/10781552221135121"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/60.22.2314"},{"key":"e_1_3_3_8_2","first-page":"153","article-title":"Use of a closed system device to reduce occupational contamination and exposure to antineoplastic drugs in the hospital work environment","volume":"53","author":"Yoshida J","year":"2009","unstructured":"Yoshida J, Tei G, Mochizuki C, et al. Use of a closed system device to reduce occupational contamination and exposure to antineoplastic drugs in the hospital work environment. 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