{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:49:13Z","timestamp":1777700953384,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant Nos. 82003344"],"award-info":[{"award-number":["Grant Nos. 82003344"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","award":["ZR2020QH137"],"award-info":[{"award-number":["ZR2020QH137"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    Psoriasis is an immune-mediated chronic inflammatory disease characterized by keratinocyte hyperproliferation and inflammatory cell infiltration. While noncoding RNAs are implicated in its progression, research remains limited. Integrating lncRNA microarray data with LncRNASNP2-based predictions identified the long noncoding RNA (lncRNA)\n                    <jats:italic toggle=\"yes\">HSFY2-10:1<\/jats:italic>\n                    as a potential functional lncRNA contributing to psoriasis pathogenesis. This study aimed to investigate the role of lnc-\n                    <jats:italic toggle=\"yes\">HSFY2-10:1<\/jats:italic>\n                    \/miR-145-5p\/fibronectin (FN1) axis in psoriasis. We found that\n                    <jats:italic toggle=\"yes\">HSFY2-10:1<\/jats:italic>\n                    was significantly upregulated in psoriatic tissues. In a psoriasis cell model established by stimulating NHEKs and HaCaT cells with the M5 cytokine cocktail (IL-17A, IL-22, oncostatin M, IL-1\u03b1, and TNF-\u03b1), lnc-HSFY2-10:1 promoted keratinocyte hyperproliferation and CCL20 secretion. Mechanistically,\n                    <jats:italic toggle=\"yes\">HSFY2-10:1<\/jats:italic>\n                    functioned as a competitive endogenous RNA for miR-145-5p, thereby regulating FN1 expression. Overexpression of miR-145-5p markedly reversed the\n                    <jats:italic toggle=\"yes\">HSFY2-10:1<\/jats:italic>\n                    -induced upregulation of FN1, keratinocyte proliferation, and CCL20 secretion. These findings indicate that the lnc-\n                    <jats:italic toggle=\"yes\">HSFY2-10:1<\/jats:italic>\n                    \/miR-145-5p\/FN1 axis plays a crucial role in psoriasis pathogenesis and serves as a potential therapeutic target.\n                  <\/jats:p>","DOI":"10.1177\/10799907251376857","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T14:00:21Z","timestamp":1757944821000},"page":"375-384","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lnc-\n                    <i>HSFY2-10:1<\/i>\n                    Contributes to Keratinocyte Proliferation and Psoriatic Inflammation Through miR-145-5p\/FN1 Axis"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-8173","authenticated-orcid":false,"given":"Luan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Jinan Dermatosis Prevention and Control Hospital, Jinan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, PR China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenqiang","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Jinan Dermatosis Prevention and Control Hospital, Jinan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Qingdao Municipal Hospital, Qingdao, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)84980-3"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11124"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/PTT.S328460"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.08.014"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11535"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12846"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antib12020030"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14219"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902464"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9991175"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.06.025"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae973"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.09.004"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158751"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-021-01528-0"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.12.011"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09737.x"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102846"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.01.008"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b01258"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.09.023"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005041"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-3449-2_8"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.790924"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00871.x"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-024-01995-7"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-18587-w"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1640-x"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.9993"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17256"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12081072"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9050478"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.890624"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2024.101967"}],"container-title":["Journal 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