{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:49:08Z","timestamp":1777700948907,"version":"3.51.4"},"reference-count":57,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    C-X-C chemokine receptor 4 (CXCR4) is a chemokine receptor. Paired box protein 5 (PAX5) is a nuclear transcription factor. Octamer-binding protein 2 (OCT2) is a B-cell-restricted transcription factor. This study aimed to evaluate the protein expression of CXCR4, PAX5, and OCT2, as well as the gene expression of long noncoding RNA (lncRNA) X-inactive specific transcript (XIST)\/miR-34\/PAX5, in diffuse large B-cell lymphoma (DLBCL). The study included 67 patients with DLBCL and 15 lymphoid tissue samples from reactive lymph nodes. Immunohistochemical (IHC) methods were used to evaluate protein expression. Gene expression was measured by real-time polymerase chain reaction. Correlation analysis showed significant negative correlations between miR-34 expression and each of the\n                    <jats:italic toggle=\"yes\">XIST<\/jats:italic>\n                    expression (r = \u22120.41,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001) and\n                    <jats:italic toggle=\"yes\">PAX5<\/jats:italic>\n                    expression (r = \u22120.43,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001). At the same time, there was a strong positive correlation between\n                    <jats:italic toggle=\"yes\">XIST<\/jats:italic>\n                    expression and\n                    <jats:italic toggle=\"yes\">PAX5<\/jats:italic>\n                    expression (r = 0.92,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001). In conclusion, our findings indicate that CXCR4, OCT2, and PAX5 IHC expressions can be considered diagnostic markers in DLBCL. In addition, the\n                    <jats:italic toggle=\"yes\">XIST\/miR-34\/PAX5<\/jats:italic>\n                    axis may serve as a potential diagnostic marker in DLBCL. Moreover, CXCR4 and\n                    <jats:italic toggle=\"yes\">XIST\/miR-34\/PAX5<\/jats:italic>\n                    expressions may be potential prognostic markers in DLBCL.\n                  <\/jats:p>","DOI":"10.1177\/10799907251379845","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:13:16Z","timestamp":1758906796000},"page":"344-359","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["CXCR 4, PAX5, and OCT2 Immunohistochemical Expressions in Diffuse Large B-Cell Lymphoma and Their Relationship with XIST\/miR-34\/PAX5 Axis"],"prefix":"10.1177","volume":"45","author":[{"given":"Noha F.","family":"Elaidy","sequence":"first","affiliation":[{"name":"Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-1608","authenticated-orcid":false,"given":"Samia","family":"Hussein","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoda F.","family":"Ebian","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha Mahmoud Hamed","family":"Sakr","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Barakat","family":"Waley","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa M.","family":"Hendawy","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba Mahmoud","family":"Abdelgeleel","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham","family":"Sameh","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, 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