{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:50:44Z","timestamp":1777701044054,"version":"3.51.4"},"reference-count":45,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Zhejiang TCM science and technology plan","award":["No. 2023ZL536"],"award-info":[{"award-number":["No. 2023ZL536"]}]},{"name":"Zhejiang Health science and technology plan","award":["No. 2024XY118"],"award-info":[{"award-number":["No. 2024XY118"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Bushen Huoxue Acupuncture shows potential in treating neurodegenerative diseases, but its mechanisms remain incompletely understood. Using the senescence-accelerated mouse-prone 8 (SAMP8) mouse model, we assessed cognitive function via the Morris water maze test, hippocampal neuronal apoptosis with terminal deoxynucleotidyl transferase dUTP nick end labeling staining, and microglial activation through immunohistochemistry. Serum levels of inflammatory cytokines [tumor necrosis factor-alpha, interleukin (IL)-1\u03b2, and IL-6] were quantified by enzyme-linked immunosorbent assay. The expression of SIRT2 pathway-related proteins, along with A\u03b2 deposition, was analyzed using Western blotting, immunohistochemistry, and immunofluorescence. The results demonstrated that Bushen Huoxue Acupuncture improved cognitive function in SAMP8 mice, reducing hippocampal neuronal apoptosis and decreasing serum levels of pro-inflammatory cytokines. Additionally, it reduced the levels of A\u03b242, a more aggregation-prone and toxic A\u03b2 subtype, in both hippocampal tissues and serum, as well as the number of CD68-positive cells in hippocampal tissues, suggesting the inhibition of amyloid pathology and neuroinflammatory. The treatment also downregulated SIRT2, BACE1, and APP-CTF while increasing RTN4B expression. Notably, Bushen Huoxue Acupuncture outperformed non-acupoint acupuncture in enhancing cognitive function and reducing inflammation. Our findings indicate that Bushen Huoxue Acupuncture alleviates cognitive deficits and neuroinflammation by suppressing the SIRT2-mediated RTN4B\/BACE1 pathway, highlighting acupuncture as a promising therapy for neurodegenerative diseases.<\/jats:p>","DOI":"10.1177\/10799907251391519","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T08:50:41Z","timestamp":1763455841000},"page":"22-31","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bushen Huoxue Acupuncture Suppresses the Release of Inflammation Cytokines in a Mouse Model of Neurodegenerative Disease by Modulating the SIRT2\/RTN4B\/BACE1 Pathway"],"prefix":"10.1177","volume":"46","author":[{"given":"Hongqin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liquan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hangzhou Chenghong Hospital, Hangzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-022-00795-9"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1665-3"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33118"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11726-014-0804-8"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx104"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102210"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.02.001"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1081938"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-2064-x"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imr.2022.100919"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-00435-y"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.12659\/msm.913858"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad-200063"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.02.077"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5567697"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.focus.20160030"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jams.2020.11.002"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2016.12.009"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010107"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-022-01332-9"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03179-1"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094850"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.22027"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.563446"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3981"},{"issue":"11","key":"e_1_3_5_27_1","first-page":"2855","article-title":"Effects of serum acetyl choline and amyloid-beta protein by using acupuncture Baihui (GV20) and Yongquan (KI1) acupoint to treat patients with Alzheimer disease","volume":"13","author":"Sun H","year":"2018","unstructured":"Sun H, , Zhu M, , Zhang W. 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