{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:43:30Z","timestamp":1793929410229,"version":"4.8.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Postgraduate Research & Practice Innovation Program of Jiangsu Province","award":["SJCX24_0982"],"award-info":[{"award-number":["SJCX24_0982"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82474139"],"award-info":[{"award-number":["82474139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>The rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) poses a critical public health challenge, yet current diagnostic and therapeutic approaches remain limited. Interleukin-11 (IL-11) is a pro-inflammatory cytokine expressed by various cell types in the liver. Although preclinical studies have revealed the pro-fibrotic role of IL-11 in mouse models, the clinical relevance between serum IL-11 and human MASLD remains unclear. This cross-sectional study enrolled 375 patients with MASLD from the outpatient department to explore the relationship between the serum level of IL-11 and the indicators of MASLD in adults with MASLD. Demographic characteristics, clinical parameters, laboratory biomarkers, FibroScan results, and serum IL-11 concentrations were prospectively collected in patients with MASLD for further analysis. As a result, the liver stiffness measurement values were significantly elevated in patients with detectable serum IL-11 compared to the IL-11-undetectable group, while the controlled attenuation parameter values between the groups showed no significant difference. It was also illustrated by logistic regression models that serum IL-11 is an independent predictor of advanced hepatic fibrosis. Our findings provide the references for further developing IL-11 as a potential evaluative biomarker and therapeutic target of MASLD.<\/jats:p>","DOI":"10.1177\/10799907261432064","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T10:14:25Z","timestamp":1773483265000},"page":"204-211","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum Level of Interleukin-11 Is Associated with the Severity of Hepatic Fibrosis in Adults with Metabolic Dysfunction-Associated Steatotic Liver Disease"],"prefix":"10.1177","volume":"46","author":[{"given":"Yingying","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China."},{"name":"Key Laboratory for Metabolic Diseases in Chinese Medicine, Nanjing University of Chinese Medicine, 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