{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:40:19Z","timestamp":1792680019188,"version":"4.5.0"},"reference-count":51,"publisher":"SAGE Publications","issue":"11-12","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Council of Science and Technology","award":["SSA\/IMSS\/ISSSTE-CONACYT 2015-262133, FSSEP02-CB"],"award-info":[{"award-number":["SSA\/IMSS\/ISSSTE-CONACYT 2015-262133, FSSEP02-CB"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:p>\n                    Maintaining optimal health in childhood is essential for proper physical, motor, and neurological development. A balanced gut microbiota and adequate micronutrient intake support immune regulation, preservation of the intestinal barrier, and reduction of chronic inflammation. In contrast, unhealthy diets are linked to lower nutrient intake and disruptions in gut microbial composition. In this cross-sectional study of 209 children aged 6\u201312 years in Mexico City, we evaluated the interaction between the relative abundance of\n                    <jats:italic toggle=\"yes\">B. longum<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">B. adolescentis<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">B. breve<\/jats:italic>\n                    and the intake of zinc, omega-3 fatty acids, and vitamin D, and their association with serum cytokines (IL-6, IL-10, tumor necrosis factor-alpha, and adiponectin) using logistic regression models. We observed that children with low\n                    <jats:italic toggle=\"yes\">B. adolescentis<\/jats:italic>\n                    abundance and low zinc intake had higher odds of elevated IL-6 levels. Similarly, low\n                    <jats:italic toggle=\"yes\">B. adolescentis<\/jats:italic>\n                    abundance combined with low vitamin D intake was associated with increased odds of elevated IL-6. Low\n                    <jats:italic toggle=\"yes\">B. breve<\/jats:italic>\n                    abundance with low zinc intake also showed higher odds of elevated IL-6. Conversely, low\n                    <jats:italic toggle=\"yes\">B. longum<\/jats:italic>\n                    abundance with low vitamin D and omega-3 intake was associated with higher odds of elevated IL-10 levels. These findings suggest that reduced\n                    <jats:italic toggle=\"yes\">Bifidobacterium<\/jats:italic>\n                    abundance, combined with low micronutrient intake, is associated with altered cytokine profiles, contributing to immune dysregulation and inflammation in children.\n                  <\/jats:p>","DOI":"10.1177\/10799907261470545","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:22:21Z","timestamp":1785172941000},"page":"352-361","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Low Gut\n                    <i>Bifidobacterium<\/i>\n                    Relative Abundance and Low Intake of Zinc, Omega-3 Fatty Acids, and Vitamin D Are Associated With Inflammation in Children"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6907-7150","authenticated-orcid":false,"given":"Cinthia Denisse","family":"P\u00e9rez-Carrillo","sequence":"first","affiliation":[{"name":"Escuela de Salud P\u00fablica de M\u00e9xico, Instituto Nacional de Salud P\u00fablica, Cuernavaca, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Ayala-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Sobre Enfermedades Infecciosas, Instituto Nacional de Salud P\u00fablica, Cuernavaca, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinthya Estefhany","family":"D\u00edaz-Ben\u00edtez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Sobre Enfermedades Infecciosas, Instituto Nacional de Salud P\u00fablica, Cuernavaca, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Lagunas-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Sobre Enfermedades Infecciosas, Instituto Nacional de Salud P\u00fablica, Cuernavaca, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Bahena-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Sobre Enfermedades Infecciosas, Instituto Nacional de Salud P\u00fablica, Cuernavaca, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilia","family":"Ju\u00e1rez-Palma","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Sobre Enfermedades Infecciosas, Instituto Nacional de Salud P\u00fablica, Cuernavaca, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Cruz","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Bioqu\u00edmica, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de M\u00e9xico, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4645-2494","authenticated-orcid":false,"given":"Ana Isabel","family":"Burguete-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Sobre Enfermedades Infecciosas, Instituto Nacional de Salud P\u00fablica, Cuernavaca, M\u00e9xico."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"issue":"2","key":"e_1_3_5_2_1","first-page":"88","article-title":"La obesidad como un proceso inflamatorio [Obesity as an inflammatory process]","volume":"67","author":"Blancas-Flores G","year":"2010","unstructured":"Blancas-Flores G, , Almanza-P\u00e9rez JC, , L\u00f3pez-Roa RI, et al. La obesidad como un proceso inflamatorio [Obesity as an inflammatory process]. 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Validaci\u00f3n de un cuestionario corto de frecuencia de consumo alimentario en ni\u00f1os peque\u00f1os [Validation of a short food frequency questionnaire in small children]. 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