{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:51Z","timestamp":1792787691145,"version":"4.5.0"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"},{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004878","name":"Funda\u00e7\u00e3o de Ensino e Pesquisa de Uberaba","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004878","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"},{"id":"https:\/\/ror.org\/00nc55f03","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"},{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interferon &amp; Cytokine Research"],"abstract":"<jats:p>\n                    The objective of this study was to evaluate the association between immunostaining of tumor necrosis factor-alpha (TNF-\u03b1) and its receptors in the stroma of malignant ovarian neoplasm with hemogram parameters and tumor markers. Women with a confirmed diagnosis of malignant or borderline ovarian neoplasm were included (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 43). Age, hormonal status, histological type, histological grade, staging, type of carcinogenesis, and blood count parameters were recorded. For the immunohistochemical study, TNF-\u03b1 and its receptors were evaluated in peritumoral stroma. Receiver operating characteristic curve and multivariate analysis were performed. The level of significance was &lt;0.05. For TNF-\u03b1, there was statistical significance for basophils (cutoff value &gt;0) and neutrophils (cutoff value \u22643,900) between strong and weak immunostaining. In relation to TNF-\u03b1 receptor 1 (TNFR1), a cutoff value of monocytes &gt;312 per mm\n                    <jats:sup>3<\/jats:sup>\n                    was found. Regarding TNF-\u03b1 receptor 2 (TNFR2), the cutoff value of CA-125 was \u226495.16 U\/mL. Still regarding TNFR2, the cutoff value for the absolute platelet count was \u2264298,000 per mm\n                    <jats:sup>3<\/jats:sup>\n                    . Multivariate analysis showed that an absolute monocyte count &gt;312 per mm\n                    <jats:sup>3<\/jats:sup>\n                    is associated with strong stromal immunostaining of TNFR1, and a platelet count \u2264298,000 per mm\n                    <jats:sup>3<\/jats:sup>\n                    is associated with strong stromal immunostaining of TNFR2. Therefore, an absolute monocyte count &gt;312 per mm\n                    <jats:sup>3<\/jats:sup>\n                    is associated with strong stromal immunostaining of TNFR1, and a platelet count \u2264298,000 per mm\n                    <jats:sup>3<\/jats:sup>\n                    is associated with strong stromal immunostaining of TNFR2.\n                  <\/jats:p>","DOI":"10.1177\/10799907261487838","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:48:29Z","timestamp":1789480109000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stromal Expression of TNF-\u03b1 and Its Receptors TNFR1 and TNFR2: Association with Blood Count Parameters in Ovarian Cancer"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6591-7619","authenticated-orcid":false,"given":"Rosekeila Sim\u00f5es","family":"Nomelini","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Laboratory of Applied Sciences for Women (LaCam), Federal University of Tri\u00e2ngulo Mineiro, Uberaba, Brazil."},{"name":"Graduate Program in Gynecology and Obstetrics of the Ribeir\u00e3o Preto Medical School of the University of S\u00e3o Paulo (FMRP-USP), Ribeir\u00e3o Preto, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela Mois\u00e9s Maluf","family":"Sanguinete","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Laboratory of Applied Sciences for Women (LaCam), Federal University of Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00edcia Chagas","family":"Modesto","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Laboratory of Applied Sciences for Women (LaCam), Federal University of Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcia Fernanda Barros","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Laboratory of Applied Sciences for Women (LaCam), Federal University of Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neila Caroline Alves","family":"Amaral","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Laboratory of Applied Sciences for Women (LaCam), Federal University of Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Millena Prata","family":"Jammal","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Laboratory of Applied Sciences for Women (LaCam), Federal University of Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli\u00e2ngela de Castro","family":"C\u00f4bo","sequence":"additional","affiliation":[{"name":"Surgical Pathology Service, Federal University of Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Margarida","family":"Etchebehere","sequence":"additional","affiliation":[{"name":"Surgical Pathology Service, Federal University of Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie Fernando Candido","family":"Murta","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Laboratory of Applied Sciences for Women (LaCam), Federal University of Tri\u00e2ngulo Mineiro, Uberaba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010033"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.10.008"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10042-008-0117-1"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-07513-w"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-019-0527-z"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2013.07.003"},{"issue":"6","key":"e_1_3_6_8_1","first-page":"5657","article-title":"Ovarian cancer-induced immunosuppression: Relationship to tumor necrosis factor-\u03b1 (TNF-\u03b1) release from ovarian tissue","volume":"19","author":"Hassan MI","year":"1999","unstructured":"Hassan MI, , Kassim SK, , Saeda L, et al. Ovarian cancer-induced immunosuppression: Relationship to tumor necrosis factor-\u03b1 (TNF-\u03b1) release from ovarian tissue. Anticancer Res 1999;19(6C):5657\u20135662.","journal-title":"Anticancer Res"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-9-38"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101217"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.66.1.61"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9271"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2014.01.005"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-018-0508-3"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_304_17"},{"issue":"3","key":"e_1_3_6_16_1","first-page":"364","article-title":"Parameters of blood count and tumor markers: A retrospective analysis and relation to prognostic factors in ovarian cancer","volume":"38","author":"Nomelini RS","year":"2017","unstructured":"Nomelini RS, , de Carvalho Oliveira LJ, , Tavares-Murta BM, et al. Parameters of blood count and tumor markers: A retrospective analysis and relation to prognostic factors in ovarian cancer. Eur J Gynaecol Oncol 2017;38(3):364\u2013367.","journal-title":"Eur J Gynaecol Oncol"},{"issue":"2","key":"e_1_3_6_17_1","first-page":"745","article-title":"Distinct expression and localization of TNF system in ovarian carcinoma tissues: Possible involvement of TNF-\u03b1 in morphological changes of ovarian cancerous cells","volume":"34","author":"Piura B","year":"2014","unstructured":"Piura B, , Medina L, , Rabinovich A, et al. Distinct expression and localization of TNF system in ovarian carcinoma tissues: Possible involvement of TNF-\u03b1 in morphological changes of ovarian cancerous cells. 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