{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:45:26Z","timestamp":1777934726226,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100015153","name":"Fondation Air Liquide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019979","name":"Fondation Universit\u00e9 Grenoble Alpes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019979","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-12-TECS-0010"],"award-info":[{"award-number":["ANR-12-TECS-0010"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-IDEX-02"],"award-info":[{"award-number":["ANR-15-IDEX-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonds de dotation AGIR pour les maladies chroniques"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Wilderness &amp; Environmental Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Headache is a hallmark symptom of chronic mountain sickness (CMS), a high altitude disease thought to be induced by excessive erythrocytosis (EE) in highlanders. Nevertheless, headache characteristics related to permanent high altitude residence remain understudied, as does the association between headache occurrence and hemoglobin concentration ([Hb]) in highlanders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A pilot cross-sectional study was conducted in La Rinconada, Peru (altitude 5100\u2005m), over a 2-y period. During all comers\u2019 medical consultations, highlanders with no known history of chronic medical conditions (except EE\/CMS) were questioned regarding headache symptoms. Headache characteristics were collected as well as clinical data and [Hb].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Headache prevalence was 61% (200 of 330 highlanders). Clinical characteristics of headache attacks (ie, location, onset, intensity, quality, and duration) were similar between highlanders with and without EE. In multivariate analysis, headache occurrence was associated with lower oxygen saturation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), higher body mass index (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), and lower self-reported sleep duration (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) but not with [Hb] or sex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The absence of a statistically significant association between headache occurrence and [Hb] questions the use of headache as a symptom reflecting EE in CMS highlanders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10806032251376313","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:51:54Z","timestamp":1758045114000},"page":"64-69","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["High Altitude Headache in Highlanders: A Hallmark Symptom of Chronic Mountain Sickness Related to Excessive Erythrocytosis? A Preliminary Report from the World's Highest City"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4491-1004","authenticated-orcid":false,"given":"Ivan","family":"Hancco Zirena","sequence":"first","affiliation":[{"name":"University of Grenoble Alpes, Inserm, CHU Grenoble Alpes"},{"name":"Universidad de San Martin de Porres"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9520-6401","authenticated-orcid":false,"given":"Alberto","family":"Florez Prada","sequence":"additional","affiliation":[{"name":"Grenoble Alpes University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0585-4155","authenticated-orcid":false,"given":"Daniel Enrique","family":"Rojas Bolivar","sequence":"additional","affiliation":[{"name":"Universidad Nacional Mayor de San Marco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6080-5738","authenticated-orcid":false,"given":"Andrea","family":"Marengo","sequence":"additional","affiliation":[{"name":"Universidad Nacional de Cuyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanis","family":"Micha","sequence":"additional","affiliation":[{"name":"University of Grenoble Alpes, Inserm, CHU Grenoble Alpes"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8816-0356","authenticated-orcid":false,"given":"St\u00e9phane","family":"Doutreleau","sequence":"additional","affiliation":[{"name":"University of Grenoble Alpes, Inserm, CHU Grenoble Alpes"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8076-9861","authenticated-orcid":false,"given":"Julien V.","family":"Brugniaux","sequence":"additional","affiliation":[{"name":"University of Grenoble Alpes, Inserm, CHU Grenoble Alpes"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0831-9222","authenticated-orcid":false,"given":"Samuel","family":"Verges","sequence":"additional","affiliation":[{"name":"University of Grenoble Alpes, Inserm, CHU Grenoble Alpes"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0922-5102","authenticated-orcid":false,"given":"Benoit","family":"Champigneulle","sequence":"additional","affiliation":[{"name":"University of Grenoble Alpes, Inserm, CHU Grenoble Alpes"},{"name":"Department of Anesthesia and Critical Care, CHU Grenoble Alpes, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00526-w"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP284553"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2003.12.014"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.00973.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1994.1405339.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-024-01759-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2013.06.006"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00773"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP284550"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2005.6.147"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-3"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.11.030"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP279694"}],"container-title":["Wilderness &amp; 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