{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:13:19Z","timestamp":1786374799347,"version":"build-2736575974"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Wilderness &amp; Environmental Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pulmonary B-lines can be seen on lung ultrasound (LUS) and indicate the presence of pulmonary edema, as is seen in high-altitude pulmonary edema (HAPE). While asymptomatic B-lines have been observed in high-altitude travelers without clinical HAPE, their prevalence and relationship to high-altitude physiology remain poorly understood. This study aims to characterize B-line development in high-altitude travelers and its relationship to physiologic changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational study investigated adult trekkers in Nepal's Khumbu Valley. An 8-point LUS was performed to obtain a B-line quantification score. Altitude (2610\u20135364\u2005m), vital signs, and Lake Louise score (LLS) for acute mountain sickness (AMS) were also recorded. A subset of participants was followed longitudinally as they ascended. Regression analyses were performed to compare the B-line score with altitude, pulse oximetry (SpO2), and LLS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 88 subjects were enrolled, and 21 of these were followed longitudinally. There was a significant positive correlation between altitude and B-line score (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.18,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.049) in the general population; however, this finding was not significant in the longitudinal group (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.21,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.13). B-line score was inversely correlated with resting SpO2 (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009-0.3,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.0008). There was no significant relationship between B-line score and LLS (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.14,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.12).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LUS B-line scores were higher with increases in altitude, and resting SpO2 decreased with higher B-line scores. B-line scores were not correlated with the development of symptoms of AMS. More research is needed to elucidate the clinical significance of these asymptomatic findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10806032251397958","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T13:34:40Z","timestamp":1764768880000},"page":"378-384","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["B-line Prevalence Is Higher with Increases in Altitude but Does Not Correlate with AMS Symptomatology"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6062-9068","authenticated-orcid":false,"given":"Tiana","family":"Linkus","sequence":"first","affiliation":[{"name":"University of Colorado School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Biggin","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-493X","authenticated-orcid":false,"given":"Brian","family":"Strickland","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-006-0046-z"},{"key":"e_1_3_3_3_2","first-page":"8","volume-title":"Auerbach\u2019s Wilderness Medicine","author":"Hackett PH","year":"2017","unstructured":"Hackett PH, Luks AM, Lawley JS, Roach RC. High altitude medicine and pathophysiology. In: Auerbach PS, ed. Auerbach\u2019s Wilderness Medicine. 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