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This review highlights its efficacy in treating corneal diseases, glaucoma, uveitis, cataracts, and retinal\/optic nerve disorders, supported by evidence from both traditional Chinese medicine formulations and modern pharmacological studies. Key advancements in delivery systems (e.g., nanocarriers, intravitreal hydrogels) address its solubility challenges and enhance bioavailability. Despite promising preclinical results, clinical translation requires optimization of dosing regimens and validation through rigorous trials. Baicalein\u2019s multifaceted action positions it as a potent natural candidate for managing inflammation, oxidative stress, and vascular pathologies in ophthalmology, warranting further research to bridge mechanistic insights with therapeutic applications.\n                  <\/jats:p>","DOI":"10.1177\/10807683251370549","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:58:01Z","timestamp":1759481881000},"page":"490-502","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Baicalein in Ophthalmology: Recent Progress and Emerging Therapeutic Applications"],"prefix":"10.1177","volume":"41","author":[{"given":"Haifeng","family":"Ma","sequence":"first","affiliation":[{"name":"School of Optometry, Jiangxi Medical College, Nanchang University, No. 463 Bayi Avenue, Nanchang City 330006, Jiangxi Province, China."},{"name":"Jiangxi Research Institute of Ophthalmology and Visual 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