{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:30:51Z","timestamp":1787135451386,"version":"build-2736575974"},"reference-count":44,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of subliminal subthreshold laser (SubCyclo) in reducing peak intraocular pressure (IOP) using the water-drinking test (WDT) in patients with refractory glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective interventional study included 50 eyes of 49 patients with moderate-to-advanced refractory glaucoma treated with SubCyclo using a standardized protocol. WDT was performed at baseline, 1, 3, and 6 months postoperatively. Surgical success was defined as: Criterion A, IOP &lt; 21 mmHg or \u2265 20% reduction from baseline; and Criterion B, IOP &lt; 21 mmHg and \u2265 20% reduction. The number of medications, reasons for patient exclusion, and sensitivity analyses comparing patients with \u2265 3 months versus &lt; 3 months follow-up were assessed. Safety outcomes included complications and hypotony.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean baseline basal and peak IOP was 23.2 \u00b1 8.9 mmHg and 27.8 \u00b1 11.1 mmHg, respectively. At 6 months, basal IOP was 20.1 \u00b1 8.6 mmHg (13.5% reduction,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.18), and peak IOP was 25.8 \u00b1 10.3 mmHg (7.2% reduction,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.73). Surgical success at 6 months was 38% (criterion A) and 20% (criterion B). Kaplan\u2013Meier analysis showed cumulative failure rates of 64.8% and 81.5%, respectively. Mean medications decreased from 4.1 \u00b1 1.02 to 3.72 \u00b1 1.40 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.34) at 6 months. No hypotony, vision-threatening complications, or persistent inflammation were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SubCyclo showed a favorable safety profile, but did not significantly reduce peak IOP as measured by WDT in refractory glaucoma. These findings highlight the need to refine treatment parameters and identify subgroups most likely to benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10807683261417554","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T13:08:01Z","timestamp":1770210481000},"page":"299-305","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Peak Intraocular Pressure Reduction in the Water-Drinking Test and Safety of Subliminal Subthreshold Laser"],"prefix":"10.1177","volume":"42","author":[{"given":"Carolina N.","family":"Susanna","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Martines","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda N.","family":"Susanna","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Germano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remo","family":"Susanna","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Hatanaka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307674"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.6.793"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.06.035"},{"issue":"1","key":"e_1_3_2_5_2","first-page":"49","article-title":"Water drinking and outflow facility","volume":"14","author":"Kronfeld C","year":"1975","unstructured":"Kronfeld C. 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