{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T23:59:15Z","timestamp":1785110355261,"version":"3.55.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Science Foundation of Anhui Medical University","award":["2023XKJ168"],"award-info":[{"award-number":["2023XKJ168"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82271118"],"award-info":[{"award-number":["82271118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Key Research Project of China","award":["2022YFC2404502"],"award-info":[{"award-number":["2022YFC2404502"]}]},{"name":"Tianjin Key Medical Discipline Construction","award":["TJYXZDXK-3-004A-3"],"award-info":[{"award-number":["TJYXZDXK-3-004A-3"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Up to 46%\u201364% of individuals with diabetes exhibit corneal abnormalities, including epithelial dysfunction and reduced sensitivity, which may gradually impair corneal transparency. Corneal fibroblasts regulate scar formation and play a critical role in maintaining corneal transparency. This study investigated the effects of high-glucose levels on fibroblasts and elucidated the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Human corneal stromal fibroblasts were isolated by collagenase digestion of fresh corneal stromal lenticules, obtained from small incision corneal lens extraction surgery, and cultured with different glucose concentrations (5.5\u201330 mM). The phosphorylated platelet-derived growth factor receptor beta (p-PDGFR\u03b2)\/PDGFR\u03b2) ratio, fibroblast proliferation, migration, fibrotic markers, and interleukin-6 (IL-6) expression were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Human corneal stromal fibroblast proliferation increased with increasing glucose concentrations, and a glucose concentration of 30 mM was selected for subsequent high-glucose treatment experiments. The p-PDGFR\u03b2\/PDGFR\u03b2 ratio, fibroblast proliferation, migration, fibrotic markers, and IL-6 expression were enhanced in the high-glucose group compared with those in the control group. These effects were inhibited by treatment with AG1295, a PDGFR\u03b2 tyrosine kinase inhibitor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In patients with diabetes, fibroblasts may aggregate at sites of corneal injury, potentially promoting scar hyperplasia and reducing corneal transparency. These changes may be reversed by PDGFR\u03b2 phosphorylation inhibitors, suggesting new therapeutic avenues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10807683261433333","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:25:24Z","timestamp":1773901524000},"page":"420-429","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["AG1295 Attenuates High-Glucose-Induced Proliferation, Migration, Phenotype Transition, and Interleukin-6 Expression in Human Corneal Stromal Fibroblasts"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-3967","authenticated-orcid":false,"given":"Yuwei","family":"Zheng","sequence":"first","affiliation":[{"name":"Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin, China."},{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Wan","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Eye Hospital, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Eye Hospital, Tianjin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.05.033"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1079541"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2021.101135"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios13110974"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology13030144"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2023.10.12"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2023.05.017"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.63.1.22"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-024-02969-7"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2023.05.005"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010178"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.156047"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.996635"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-51707-2"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.09.001"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.23-0154"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01396-7"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125249"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114983"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2022.10.032"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10839"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16912"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2023.104949"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0311828"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-024-06785-9"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5155(02)00698-6"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202952"}],"container-title":["Journal of Ocular Pharmacology and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10807683261433333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10807683261433333","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10807683261433333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T23:18:38Z","timestamp":1785107918000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10807683261433333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1177\/10807683261433333"],"URL":"https:\/\/doi.org\/10.1177\/10807683261433333","relation":{},"ISSN":["1080-7683","1557-7732"],"issn-type":[{"value":"1080-7683","type":"print"},{"value":"1557-7732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,18]]}}}