{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T14:26:11Z","timestamp":1786890371674,"version":"build-2736575974"},"reference-count":32,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"College-level Project Fund of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine","award":["Grant No. ynts202213"],"award-info":[{"award-number":["Grant No. ynts202213"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purposes:<\/jats:title>\n                    <jats:p>Ischemic retinopathies are characterized by hypoxia-driven inflammation and pathological neovascularization (NV), with vascular endothelial growth factor (VEGF) as a central mediator. Incomplete responses to anti-VEGF therapy suggest involvement of additional hypoxia-regulated pathways. This study investigated the contribution of stromal cell\u2013derived factor-1 (SDF-1) to VEGF-driven retinal vascular pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>SDF-1 expression, leukostasis, vascular nonperfusion (NP), and NV were assessed in oxygen-induced retinopathy, VEGF transgenic mice, and VEGF-injected mice. The SDF-1 aptamer NOX-A12 was administered alone or in combination with aflibercept. Retinal vascular pathology was quantified by immunofluorescence, and vitreous albumin levels were measured to assess vascular leakage. RNA sequencing was performed in VEGF-stimulated human umbilical vein endothelial cells treated with SDF-1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      SDF-1 expression was increased in ischemic retinas and in models of sustained VEGF overexpression (Rho P35, 2.43 \u00b1 1.34; Tet\/Opsin\/VEGF (TVOP), 0.27 \u00b1 0.31; C57 VEGF, 0.13 \u00b1 0.14; retinopathy of prematurity, 3.06 \u00b1 0.65;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0004, 0.0005, &lt; 0.0001, &lt;0.0001). SDF-1 aptamer plus aflibercept more effectively suppressed retinal leukostasis (24 h, 84.2 \u00b1 13.8 vs 122.2 \u00b1 20.8; 72 h, 22 \u00b1 10.5 vs 52.6 \u00b1 13.1; Rho\/VEGF P21, 20.2 \u00b1 7.79 vs 37.4 \u00b1 9.07; Rho\/VEGF P35, 20.8 \u00b1 7.63 vs 39.7 \u00b1 8.83; TVOP, 35.3 \u00b1 9.16 vs 170.6 \u00b1 40.9, all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001), NP area (80.92 \u00b1 3.82 vs 51.53 \u00b1 11.13;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001), hypoxia (0.23 \u00b1 0.10 vs 0.82 \u00b1 0.09;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001), and NV (0.01 \u00b1 0.01 vs 0.07 \u00b1 0.01;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001) than aflibercept alone, without additional effects on choroidal NV or vitreous albumin levels. Transcriptomic analysis revealed enrichment of pathways related to leukocyte transendothelial migration, focal adhesion, tight junctions, and extracellular matrix organization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SDF-1 functions as a cooperative mediator of VEGF-driven retinal vascular pathology. Dual targeting of SDF-1 and VEGF enhances suppression of ischemic retinal injury and NV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10807683261441054","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T02:45:41Z","timestamp":1775875541000},"page":"507-517","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["SDF-1 Inhibition Attenuates VEGF-Driven Retinal Leukostasis and Neovascularization in Ischemic Retinopathy"],"prefix":"10.1177","volume":"42","author":[{"given":"Yuhong","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyi","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Changsha Hospital of Traditional Chinese Medicine (Changsha Eighth Hospital), Changsha, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jikui","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson","family":"Gong","sequence":"additional","affiliation":[{"name":"Aptitude Medical Systems, Inc, Santa Barbara, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2639-535X","authenticated-orcid":false,"given":"Da","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI135296"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06215-3"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-019-09681-1"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00848-6"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI126655"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302776"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14875"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2022.2064541"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2022.06.042"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100906"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.05.038"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-023-00672-6"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-025-04089-2"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S535338"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170830111531"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020843"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-00974-6"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7359com"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26114992"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00764-3"},{"key":"e_1_3_3_22_1","unstructured":"21.Anonymous. 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