{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T14:26:11Z","timestamp":1786890371499,"version":"build-2736575974"},"reference-count":30,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      To assess the efficacy and safety of intense pulsed light (IPL) therapy in managing dry eye syndrome (DES) following laser-assisted\n                      <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                      keratomileusis (LASIK) surgery through a systematic review and meta-analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A comprehensive literature search was conducted across PubMed, Embase, Cochrane, Web of Science, and ClinicalTrials.gov for studies reporting outcomes of IPL treatment in post-LASIK DES. Eligible studies included randomized controlled trials, observational studies with control groups, and retrospective or prospective chart reviews. Outcomes analyzed included tear breakup time (TBUT), Ocular Surface Disease Index (OSDI) score, artificial tear use (ATU), corneal staining, lipid layer thickness, and meibomian gland function. Analyses were restricted to pre-post single-arm comparisons. Random-effects meta-analyses were conducted using inverse-variance weighting with DerSimonian-Laird estimation and Hartung-Knapp-Sidik-Jonkman adjustment. Heterogeneity was assessed using\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      and \u03c4\n                      <jats:sup>2<\/jats:sup>\n                      statistics, and design-effect corrections were applied for eye-level clustering.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Four studies met inclusion criteria, comprising 146 treated eyes. IPL was associated with a significant improvement in patient-reported symptoms measured by OSDI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005). Improvements in TBUT, ATU, corneal staining, lipid layer thickness, and meibomian gland function were directionally favorable but did not reach statistical significance after conservative correction. Between-study heterogeneity was substantial, and follow-up duration was limited (0\u201324 weeks).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>IPL therapy may improve subjective dry eye symptoms following LASIK, while objective clinical outcomes remain uncertain. Current evidence remains limited, underscoring the need for larger, controlled studies with standardized protocols and longer follow-up to further define IPL\u2019s role in managing post-surgical dry eye.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10807683261442470","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:56:57Z","timestamp":1777435017000},"page":"466-472","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intense Pulsed Light Therapy for Post-LASIK Dry Eye: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7865-5062","authenticated-orcid":false,"given":"Trevor","family":"Lin","sequence":"first","affiliation":[{"name":"Morsani College of Medicine, University of South Florida, Tampa, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Chao","sequence":"additional","affiliation":[{"name":"Morsani College of Medicine, University of South Florida, Tampa, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Kou","sequence":"additional","affiliation":[{"name":"California Northstate University College of Medicine, Elk Grove, California, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung A. Viola","family":"Lee","sequence":"additional","affiliation":[{"name":"Morsani College of Medicine, University of South Florida, Tampa, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"King","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of South Florida, Tampa, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul S.","family":"Mhaskar","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Medical Education, University of South Florida Health Morsani College of Medicine, Tampa, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Jarstad","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of South Florida, Tampa, Florida, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000159"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2016.4587"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00966-6"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2003.07.003"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.10.006"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.02.019"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9094"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.11.060"},{"issue":"5","key":"e_1_3_4_10_1","article-title":"The pathophysiology, diagnosis, and treatment of dry eye disease","volume":"112","author":"Messmer EM","year":"2015","unstructured":"9.Messmer EM. 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