{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:37:37Z","timestamp":1793648257211,"version":"4.5.1"},"reference-count":27,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2017R1A1A2A10000681"],"award-info":[{"award-number":["2017R1A1A2A10000681"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["2020R1A2C1005009"],"award-info":[{"award-number":["2020R1A2C1005009"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2023-00264409"],"award-info":[{"award-number":["RS-2023-00264409"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korean Dry Eye Society","award":["IIT No. 11"],"award-info":[{"award-number":["IIT No. 11"]}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"crossref","award":["HI17C0659"],"award-info":[{"award-number":["HI17C0659"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To compare the efficacy of 2% rebamipide clear solution and 3% diquafosol eyedrops in dry eye disease (DED) patients with short tear break-up time (tBUT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This nonrandomized retrospective, comparative observational study included 120 eyes (60 patients) divided into Group 1 (2% rebamipide, 60 eyes) and Group 2 (3% diquafosol, 60 eyes). Evaluations at baseline, 1 month, and 3 months included Ocular Surface Disease Index Questionnaire (OSDI), Schirmer I, noninvasive tBUT (NItBUT), corneal\/conjunctival staining score, meiboscore, meibum expressibility and quality, lipid thickness, tear meniscus height (TMH), impression cytology, and goblet cell density. The primary endpoint was NItBUT change at 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Both groups showed significant improvement (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.025, Bonferroni correction) in DED signs and symptoms at 1 and 3 months compared with baseline. Changes from baseline were comparable between groups for OSDI, NItBUT, corneal and conjunctival staining score, meiboscore, meibum expressibility and quality, lipid thickness, impression cytology, and goblet cell density (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). At 3 months, group 2 showed greater increases in aqueous-related parameters than group 1 (for Schirmer I, adjusted mean differences 1.31 mm, 95% CI: 0.49\u20132.13,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002; for TMH, adjusted mean differences 0.05 mm, 95% CI: 0.01\u20130.09,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In patients with short tBUT DED, both rebamipide clear solution and diquafosol eyedrops showed comparable improvement in the primary endpoint, NItBUT at 3 months, as well as in other ocular surface parameters. Under standard dosing regimens, however, diquafosol was associated with greater increases in Schirmer I test values and TMH than rebamipide clear solution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10807683261446505","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T05:30:52Z","timestamp":1777267852000},"page":"473-482","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Rebamipide Clear Solution and Diquafosol Eyedrops in Dry Eye Disease with Short Tear Break-up Time: A Retrospective, Comparative Observational Study"],"prefix":"10.1177","volume":"42","author":[{"given":"Ho Sik","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Yeouido St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoung Emily","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bucheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha-Rim","family":"So","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bucheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Seung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0310-5663","authenticated-orcid":false,"given":"Eun Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Bucheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,26]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.008"},{"issue":"4","key":"e_1_3_2_3_1","first-page":"221","article-title":"Report of the National Eye Institute\/Industry workshop on clinical trials in dry eyes","volume":"21","author":"Lemp MA","year":"1995","unstructured":"2.Lemp MA. 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