{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:10:40Z","timestamp":1788667840557,"version":"build-2803163510"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study aimed to assess the long-term management and 5-year evolution of patients with neuropathic ocular pain (NOP) associated with chronic dry eye disease (DED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Fourteen patients with NOP underwent a 5-year follow-up. Baseline and 5-year assessments included questionnaires on dry eye (Dry Eye Questionnaire 5 [DEQ-5] and Ocular Surface Disease Index), pain (Brief Pain Inventory [BPI]), anxiety\/depression disorders (Hospital Anxiety and Depression Scale), and a dedicated questionnaire on NOP characteristics (Neuropathic Ocular Pain Questionnaire), which was developed for this study. Treatment tolerance and effectiveness were rated on a 0\u20135 scale. Clinical examination, meibography, tear film analysis, corneal nerve density, and inflammation assessment using\n                      <jats:italic toggle=\"yes\">in\u00a0vivo<\/jats:italic>\n                      confocal microscopy (IVCM) were performed at both time points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Patients were predominantly women (93%) with a mean age of 41 \u00b1 17 years. High rates of comorbid anxiety\/depressive disorders (85.7%) and diffuse chronic pain (35.7%) were observed, supporting the need for multimodal care. Over 5 years, significant improvements occurred in mean neuropathic pain scores (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005), BPI scores (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003), and DEQ-5 scores (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.041). Clinical parameters remained unchanged, except for a significant decrease in IVCM inflammation score (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.004). All patients received topical ophthalmic treatments; 78.6% were treated with systemic neuropathic pain relievers, and 64.3% received psychological care. The most effective treatments included artificial tears, cyclosporine eye drops, scleral lenses, oral therapies, and autologous serum eye drops.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study provides the first long-term overview of therapeutic strategies for NOP associated with DED. Findings support a multidisciplinary approach using specific questionnaires and personalized, long-term treatments. However, controlled prospective studies are needed to establish the efficacy of specific therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10807683261475800","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:53:21Z","timestamp":1788501201000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of Neuropathic Ocular Pain Associated with Dry Eye Disease in a 5-Year Prospective Cohort"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8492-2783","authenticated-orcid":false,"given":"Alice","family":"Theuriau","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, H\u00f4pital Fondation A de Rothschild, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Wiart","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, H\u00f4pital Fondation A de Rothschild, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Labetoulle","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kremlin-Bic\u00eatre Hospital, Le Kremlin Bic\u00eatre, France."},{"name":"Department of Ophthalmology, Quinze-Vingts National Ophthalmology Hospital and Vision Institute, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Rouger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, H\u00f4pital Fondation A de Rothschild, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed-Ali","family":"Sassi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, H\u00f4pital Fondation A de Rothschild, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Cochereau","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, H\u00f4pital Fondation A de Rothschild, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Gabison","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, H\u00f4pital Fondation A de Rothschild, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Doan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, H\u00f4pital Fondation A de Rothschild, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2025.05.033"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40135-015-0073-9"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-306280"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnv070"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.263"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.10.001"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000249"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.002"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001939"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2012.01.002"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-306057"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.08.004"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.5.615"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.001"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307094"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-308214"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2012.01.007"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2009.12.010"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2015.1114853"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2003.12.005"},{"key":"e_1_3_2_22_1","first-page":"361","article-title":"The hospital anxiety and depression scale","author":"Snaith P","year":"1983","unstructured":"21.Snaith P, , Zigmond S. 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