{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:44:47Z","timestamp":1792075487713,"version":"4.4.0"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ocular Pharmacology and Therapeutics"],"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To investigate the effect of anti-inflammatory drug classes, delivery methods, and personalized regimens on ocular surface health in dry eye patients, providing evidence-based support for optimizing medication regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>\n                      We systematically reviewed 127 studies (2013\u20132023; 368 datasets). Multiple linear regression analyzed tear film breakup time (TBUT) predictors. Four pharmacokinetic models (zero-order, first-order, Higuchi, Ritger\u2014Peppas) fitted drug release; robustness and subtype heterogeneity were evaluated. Compared to NSAIDs, targeted anti-inflammatory drugs, glucocorticoids, and calcineurin inhibitors increased TBUT by 1.84s, 1.58s, and 0.97s (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). Compared to eye drops, implants\/contact lenses,\n                      <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                      gels, liposomes\/nanocapsules, and nanoemulsions increased TBUT by 1.96s, 1.51s, 1.27s, and 0.83s (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). Personalized dosing added 0.76s (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). Eye drops showed first-order release with burst effect ( R 2 R 2 = 0.984); nanoemulsions and liposomes\/nanocapsules followed Higuchi ( R 2 R 2 = 0.972) and Ritger\u2014Peppas ( R 2 R 2 = 0.992) models;\n                      <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                      gels and implants maintained zero-order release ( R 2 R 2 = 0.968, 0.992). Subtype analysis revealed aqueous-deficient dry eye responded best to calcineurin inhibitor gels, evaporative dry eye to glucocorticoid nanoemulsions, and moderate-to-severe mixed dry eye to targeted drug implants, confirmed by robustness tests. Advanced delivery technologies and subtype-tailored therapy improve patient outcomes, with zero-order release systems carrying targeted anti-inflammatory drugs offering a promising future approach.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10807683261496779","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:07:08Z","timestamp":1791893228000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Innovative Iteration of Anti-Inflammatory Therapies and Delivery Technologies for Dry Eye: A Multidimensional Perspective"],"prefix":"10.1177","author":[{"given":"Xiaochuan","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The 944th Hospital of PLA Joint Logistics Support Force, Jiuquan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0909-6427","authenticated-orcid":false,"given":"Zhanqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The 944th Hospital of PLA Joint Logistics Support Force, Jiuquan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The 944th Hospital of PLA Joint Logistics Support Force, Jiuquan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The 944th Hospital of PLA Joint Logistics Support Force, Jiuquan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The 944th Hospital of PLA Joint Logistics Support Force, Jiuquan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The 944th Hospital of PLA Joint Logistics Support Force, Jiuquan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The 944th Hospital of PLA Joint Logistics Support Force, Jiuquan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/S44402-026-00106-3"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26083922"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-29319-1"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-026-04125-4"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44197-025-00512-9"},{"key":"e_1_3_2_7_1","first-page":"108076832614465","article-title":"Comparison of rebamipide clear solution and diquafosol eyedrops in dry eye disease with short tear break-up time: A retrospective, comparative observational study","author":"Hwang SH","year":"2026","unstructured":"6.Hwang SH, , Lee EJ, , So RH, et al. Comparison of rebamipide clear solution and diquafosol eyedrops in dry eye disease with short tear break-up time: A retrospective, comparative observational study. 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