{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:46:23Z","timestamp":1777851983147,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Health Informatics J"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>A computational infrastructure to underpin complex clinical trials and medical population studies is highly desirable. This should allow access to a range of distributed clinical data sets; support the efficient processing and analysis of the data obtained; have security at its heart; and ensure that authorized individuals are able to see privileged data and no more. Each clinical trial has its own requirements on data sets and how they are used; hence a reusable and flexible framework offers many advantages. The MRC funded Virtual Organisations for Trials and Epidemiological Studies (VOTES) is a collaborative project involving several UK universities specifically to explore this space. This article presents the experiences of developing the Scottish component of this nationwide infrastructure, by the National e-Science Centre (NeSC) based at the University of Glasgow, and the issues inherent in accessing and using the clinical data sets in a flexible, dynamic and secure manner.<\/jats:p>","DOI":"10.1177\/1081180x08089317","type":"journal-article","created":{"date-parts":[[2008,5,13]],"date-time":"2008-05-13T06:32:52Z","timestamp":1210660372000},"page":"79-93","source":"Crossref","is-referenced-by-count":5,"title":["Supporting grid-based clinical trials in Scotland"],"prefix":"10.1177","volume":"14","author":[{"given":"R.O.","family":"Sinnott","sequence":"first","affiliation":[{"name":"National e-Science Centre University of Glasgow Kelvin Building Glasgow\r                        G12 8QQ, UK,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Stell","sequence":"additional","affiliation":[{"name":"National e-Science Centre,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Ajayi","sequence":"additional","affiliation":[{"name":"National e-Science Centre,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,6,1]]},"reference":[{"key":"atypb1","volume-title":"Proceedings of First IEEE\/ACM International Symposium on Cluster Computing and the Grid","author":"Foster I."},{"key":"atypb2","unstructured":"VOTES. http:\/\/www.nesc.ac.uk\/hub\/projects\/votes , August\n            2007."},{"key":"atypb3","unstructured":"OGSA-DAI. http:\/\/www.ogsadai.org.uk , August 2007."},{"key":"atypb4","unstructured":"GRO for Scotland. http:\/\/www.gro-scotland.gov.uk , August 2007"},{"key":"atypb5","volume-title":"Proceedings of National Centre for e-Social Science Conference","author":"Elliot M."},{"key":"atypb6","unstructured":"NHS Information Services Division. http:\/\/www.isdscotland.org, August 2007."},{"key":"atypb7","unstructured":"GPASS. http:\/\/www.gpass.co.uk , August 2007."},{"key":"atypb8","unstructured":"Scottish Morbidity Records. http:\/\/www.show.scot.nhs.uk\/indicators\/SMR\/Main.htm , August\n                2007."},{"key":"atypb9","unstructured":"SCI Store. http:\/\/www.show.scot.nhs.uk\/sci\/products\/store , August\n            2007."},{"key":"atypb10","unstructured":"International Statistical Classification of Disease and Related Health\n                        Problems (ICD). http:\/\/www.connectingforhealth.nhs.uk\/clinicalcoding\/classifications\/icd_10\n                , August 2007."},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/6352.001.0001"},{"key":"atypb12","unstructured":"HL7. http:\/\/www.hl7.org\/, August 2007."},{"key":"atypb13","unstructured":"SNOMED-CT. http:\/\/www.snomed.org\/snomedct\/ , August 2007."},{"key":"atypb14","unstructured":"OpenEHR. http:\/\/www.openehr.org\/ , August 2007."},{"key":"atypb15","unstructured":"DICOM. http:\/\/medical.nema.org\/ , August 2007."},{"key":"atypb16","unstructured":"Practitioners Services Group. http:\/\/www.psd.scot.nhs.uk\/ , August 2007."},{"key":"atypb17","volume-title":"TeleHealth Conference","author":"Stell A.J."},{"key":"atypb18","unstructured":"Shibboleth. http:\/\/shibboleth.internet2.edu . August 2007."},{"key":"atypb19","unstructured":"GridSphere. http:\/\/www.gridsphere.org , August 2007."},{"key":"atypb20","unstructured":"Globus. http:\/\/www.globus.org, August 2007."},{"key":"atypb21","unstructured":"Glasgow Early Adoption of Shibboleth (GLASS) Project. www.nesc.ac.uk\/hub\/projects\/glass, August 2007."},{"key":"atypb22","unstructured":"Personal communication, Ian Piper, Glasgow Southern General Hospital\n                , June 2006."},{"key":"atypb23","unstructured":"caBIG. https:\/\/cabig.nci.nih.gov\/ , August 2007."},{"key":"atypb24","unstructured":"Scottish Family Health Study. http:\/\/www.innogen.ac.uk\/Research\/The-Scottish-Family-Health-Study ,\n                August 2007."}],"container-title":["Health Informatics Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1081180X08089317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1081180X08089317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:28:39Z","timestamp":1777501719000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1081180X08089317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1177\/1081180X08089317"],"URL":"https:\/\/doi.org\/10.1177\/1081180x08089317","relation":{},"ISSN":["1460-4582","1741-2811"],"issn-type":[{"value":"1460-4582","type":"print"},{"value":"1741-2811","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}