{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:20:01Z","timestamp":1777724401193,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Since the beginning of the wide-scale anti-Coronavirus disease 2019 (COVID-19) vaccination program, sporadic cases of thyroid disease following vaccination have been reported. We describe 19 consecutive cases of COVID vaccine-related thyroid disease. Medical records were reviewed for 9 patients with Graves\u2019 disease (GD) and 10 with Thyroiditis, all of whom were diagnosed following COVID-19 vaccination. In the GD group, the median age was 45.5\u2009years, female\/male(F\/M) ratio 5:4, thyroid-stimulating immunoglobulins were elevated in seven patients. The median time from vaccination to diagnosis was 3\u2009months. Methimazole treatment was given to all but one patient. At a median follow-up of 8.5\u2009months from vaccination, three patients were still on methimazole, five went into remission (data were missing for one). In the Thyroiditis group, the median age was 47\u2009years, the F\/M ratio 7:3. Thyroiditis was diagnosed after the first, second, and third doses in one, two, and seven patients, respectively. The median time from vaccination to diagnosis was 2\u2009months. TPO antibodies were positive in three patients. All patients were euthyroid off medication at the last visit. Six patients were diagnosed in the hypothyroid phase at 2.5\u2009months from vaccination. Four resolved spontaneously at 3, 6, 4, and 8\u2009months; the other two were treated with thyroxine at 1.5 and 2\u2009months from vaccination and remained on treatment at their last visit, at 11.5 and 8.5\u2009months, respectively. Thyroid disease should be included among possible complications of COVID-19 vaccine and either a late onset or delayed diagnosis should be considered.<\/jats:p>","DOI":"10.1177\/10815589231173876","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T06:13:47Z","timestamp":1684390427000},"page":"700-706","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Short- and long-term outcomes of patients with hyper or hypothyroidism following COVID vaccine"],"prefix":"10.1177","volume":"71","author":[{"given":"Efrat","family":"Markus","sequence":"first","affiliation":[{"name":"Endocrine Institute, Shamir medical center, Zerifin, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anat","family":"Bel-Ange","sequence":"additional","affiliation":[{"name":"Endocrine Institute, Shamir medical center, Zerifin, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Benbassat","sequence":"additional","affiliation":[{"name":"Endocrine Institute, Shamir medical center, Zerifin, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Steinschneider","sequence":"additional","affiliation":[{"name":"Endocrine Institute, Shamir medical center, Zerifin, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit","family":"Koren","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"Department of Internal Medicine A, Shamir Medical Center, Zerifin, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"bibr1-10815589231173876","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10060866"},{"key":"bibr2-10815589231173876","first-page":"1","volume":"28","author":"Caron P.","year":"2022","journal-title":"Endocrine"},{"key":"bibr3-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01786-7"},{"key":"bibr4-10815589231173876","first-page":"e16045","volume":"13","author":"Oyibo SO.","year":"2021","journal-title":"Cureus"},{"key":"bibr5-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab048.1954"},{"key":"bibr6-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2021.0184"},{"key":"bibr7-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-244711"},{"key":"bibr8-10815589231173876","volume":"141","author":"Sigstad E","year":"2021","journal-title":"Tidsskr Nor Laegeforen"},{"key":"bibr9-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-246425"},{"key":"bibr10-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4812"},{"key":"bibr11-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14555"},{"key":"bibr12-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2021.10.008"},{"key":"bibr13-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103211"},{"key":"bibr14-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1947102"},{"key":"bibr15-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-021-01681-7"},{"key":"bibr16-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab822"},{"key":"bibr17-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-246432"},{"key":"bibr18-10815589231173876","first-page":"100104","volume":"23","author":"Hamouche W","year":"2022","journal-title":"J Clin Transl Endocrinol Case Rep"},{"key":"bibr19-10815589231173876","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.778964"},{"key":"bibr20-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2021.102738"},{"key":"bibr21-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-021-02902-y"},{"key":"bibr22-10815589231173876","first-page":"002807","volume":"8","author":"Pierman G","year":"2021","journal-title":"Eur J Case Rep Intern Med"},{"key":"bibr23-10815589231173876","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9101108"},{"key":"bibr24-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2021.1961815"},{"key":"bibr25-10815589231173876","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.737142"},{"key":"bibr26-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2021.100136"},{"key":"bibr27-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-021-00332-z"},{"key":"bibr28-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2021.0142"},{"key":"bibr29-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-021-02919-3"},{"key":"bibr30-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-021-01725-y"},{"key":"bibr31-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-021-01650-0"},{"key":"bibr32-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab373"},{"key":"bibr33-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-021-01707-0"},{"key":"bibr34-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1016\/j.aace.2021.12.002"},{"key":"bibr35-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1177\/23247096211063356"},{"key":"bibr36-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.2013083"},{"key":"bibr37-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-021-02898-5"},{"key":"bibr38-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01739-0"},{"key":"bibr39-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac119"},{"key":"bibr40-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac049"},{"key":"bibr41-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.151"},{"key":"bibr42-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac355"},{"key":"bibr43-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2010.07.003"},{"key":"bibr44-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2020.101412"},{"key":"bibr45-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.04.009"},{"key":"bibr46-10815589231173876","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2022.0010"},{"key":"bibr47-10815589231173876","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.617089"},{"key":"bibr48-10815589231173876","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.840668"}],"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589231173876","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10815589231173876","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589231173876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:39:51Z","timestamp":1777459191000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10815589231173876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,18]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1177\/10815589231173876"],"URL":"https:\/\/doi.org\/10.1177\/10815589231173876","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,18]]}}}