{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:47:36Z","timestamp":1787359656118,"version":"build-2736575974"},"reference-count":16,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>The objective of this observational study is to determine whether vaccination for SARS-CoV-2 alters the clinical presentation of post-COVID conditions (PCC). Self-reported data provided by patients requesting care for PCC at the Mayo Clinic were analyzed to assess for a relationship between vaccination status prior to COVID infection and PCC symptoms. In all, 477 subjects were included in this study. In total, 245 (51.4%) were vaccinated. Vaccinated subjects with PCC reported less abdominal pain, anosmia, parosmia, chest pain\/tightness, dizziness, numbness\/tingling, dyspnea, spells\/tremors, and weakness. For hospitalized patients who developed PCC, vaccinated patients reported less chest pain, cough, dizziness, and dyspnea. After applying Bonferroni correction for multiple comparisons, decreased abdominal pain remained significant. We conclude that vaccination against SARS-CoV-2 may reduce the symptoms of PCC, leading to improved morbidity and function. Further studies on the impact of vaccination on PCC and recovery are needed.<\/jats:p>","DOI":"10.1177\/10815589231191812","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T08:24:51Z","timestamp":1690446291000},"page":"889-895","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Potential reduction of post-acute sequelae of SARS-CoV-2 symptoms via vaccination"],"prefix":"10.1177","volume":"71","author":[{"given":"Greg","family":"Vanichkachorn","sequence":"first","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Gilman","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Ganesh","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mueller","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Swift","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Breeher","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Hassan","family":"Murad","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"bibr1-10815589231191812","unstructured":"World Health Organization. A clinical case definition of post COVID-19 condition by a Delphi consensus. World Health Organization. https:\/\/www.who.int\/publications\/i\/item\/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021 (2021, accessed 1 November 2022)."},{"key":"bibr2-10815589231191812","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12603"},{"key":"bibr3-10815589231191812","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7121e1"},{"key":"bibr4-10815589231191812","unstructured":"National Center for Health Statistics. Long COVID\u2014Household pulse survey\u2014COVID-19. CDC, https:\/\/www.cdc.gov\/nchs\/covid19\/pulse\/long-covid.htm (2022, accessed 1 November, 2022)."},{"key":"bibr5-10815589231191812","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01755-4"},{"key":"bibr6-10815589231191812","unstructured":"Bach K. New data shows long Covid is keeping as many as 4 million people out of work, https:\/\/www.brookings.edu\/research\/new-data-shows-long-covid-is-keeping-as-many-as-4-million-people-out-of-work\/ (2022, accessed 23 December, 2022)."},{"key":"bibr7-10815589231191812","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01840-0"},{"key":"bibr8-10815589231191812","doi-asserted-by":"crossref","first-page":"e072529","DOI":"10.1136\/bmj-2022-072529","volume":"380","author":"Mizrahi B","year":"2023","journal-title":"BMJ"},{"key":"bibr9-10815589231191812","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2021.04.024"},{"key":"bibr10-10815589231191812","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocpiqo.2022.05.007"},{"key":"bibr11-10815589231191812","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2021"},{"key":"bibr12-10815589231191812","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-022-07381-z"},{"key":"bibr13-10815589231191812","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14251"},{"key":"bibr14-10815589231191812","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191610189"},{"key":"bibr15-10815589231191812","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101019"},{"key":"bibr16-10815589231191812","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000001910"}],"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589231191812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10815589231191812","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589231191812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:39:54Z","timestamp":1777459194000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10815589231191812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,23]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1177\/10815589231191812"],"URL":"https:\/\/doi.org\/10.1177\/10815589231191812","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,23]]}}}