{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:20:35Z","timestamp":1777724435954,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>The most important complication of familial Mediterranean fever (FMF) is secondary amyloidosis. The aim of this study is to investigate the risk of developing FMF-related amyloidosis with macrophage migration inhibitory factor (MIF), interleukin 4 (IL-4), and IL-1 receptor antagonist (IL-1RA) variants. This study included 62 FMF patients with amyloidosis, 110 FMF patients without amyloidosis, and 120 controls. The clinical information of the patient groups was compared. MIF-173G\/C, IL-4 variant number tandem repeat (VNTR), and IL-1RA VNTR variants were analyzed for all participants. The use of colchicine, pleurisy, and appendectomy was more common in FMF patients with amyloidosis than in FMF patients without amyloidosis. MIF-173G\/C C\/C genotype and C allele were higher in both patient groups compared to controls. IL-1RA VNTR A1\/A2 and A1\/A4 genotypes and A1\u2013A4 alleles were more common in both patient groups than controls. The IL-4 VNTR P1 allele was more common in FMF patients with amyloidosis compared to controls. The MIF-173G\/C allele and the IL-1RA VNTR A1\u2013A4 allele are associated with FMF in the Turkish population but not with amyloidosis risk in FMF patients. The IL-4 VNTR P1 allele is more common in FMF patients with amyloidosis than in healthy individuals.<\/jats:p>","DOI":"10.1177\/10815589231207789","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:01:36Z","timestamp":1696636896000},"page":"17-25","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of MIF-173G\/C, IL-4 VNTR, and IL-1RA VNTR variants with FMF-related amyloidosis in a Turkish cohort"],"prefix":"10.1177","volume":"72","author":[{"given":"Serbulent","family":"Yigit","sequence":"first","affiliation":[{"name":"Department of Genetics, Faculty of Veterinary, Ondokuz Mayis University, Samsun, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse Feyda","family":"Nursal","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine, Hitit University, Corum, 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