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Cannabinoid hyperemesis syndrome most often presents with episodic vomiting secondary to chronic daily cannabis use over several months to years. Patients often complain of nausea and abdominal pain that is improved by taking hot showers or baths. Symptoms are alleviated with the cessation of cannabis use over a period of 6\u201312\u2009months. Treatment for acute attacks often consists of parenteral benzodiazepines in the inpatient setting. Long-term management and prevention of further attacks are aided by tricyclic antidepressants such as amitriptyline with a dose range of 50\u2013200\u2009mg\/d. Once a patient is in remission, amitriptyline can be tapered slowly. As cannabis becomes more widely available and accepted in the continental United States, so must education on the diagnosis of cannabinoid hyperemesis syndrome and treatment strategies.<\/jats:p>","DOI":"10.1177\/10815589231217495","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T02:31:41Z","timestamp":1700793101000},"page":"171-177","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Cannabinoid hyperemesis syndrome: prevalence and management in an era of cannabis legalization"],"prefix":"10.1177","volume":"72","author":[{"given":"Justin Joe","family":"Stubbs","sequence":"first","affiliation":[{"name":"Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"McCallum","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"issue":"5","key":"bibr1-10815589231217495","first-page":"219","volume":"10","author":"PAPYRUS EBERS","year":"1912","journal-title":"Cal State J Med"},{"key":"bibr2-10815589231217495","doi-asserted-by":"publisher","DOI":"10.1126\/science.1470919"},{"key":"bibr3-10815589231217495","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.036350"},{"key":"bibr4-10815589231217495","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.198"},{"key":"bibr5-10815589231217495","doi-asserted-by":"publisher","DOI":"10.3390\/ph3072163"},{"key":"bibr6-10815589231217495","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2017.04.018"},{"key":"bibr7-10815589231217495","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2017.1349910"},{"key":"bibr8-10815589231217495","first-page":"405238","volume":"2015","author":"Figueroa-Rivera IM","year":"2015","journal-title":"Case Rep Gastrointest Med"},{"key":"bibr9-10815589231217495","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/481940"},{"key":"bibr10-10815589231217495","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291706008361"},{"key":"bibr11-10815589231217495","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6511a1"},{"key":"bibr12-10815589231217495","unstructured":"United Nations. 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