{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:32:38Z","timestamp":1785353558076,"version":"3.55.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"2022 Annual Guiding Science and Technology Project of the Corps","award":["2022ZD043"],"award-info":[{"award-number":["2022ZD043"]}]},{"name":"2020 Annual University-level Scientific Research Project of Shihezi University","award":["ZZZC202013A"],"award-info":[{"award-number":["ZZZC202013A"]}]},{"name":"National Natural Science Foundation Project","award":["82060021"],"award-info":[{"award-number":["82060021"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>Liver and lung tissue damage caused by sepsis is still one of the causes of death. B-lymphocyte-induced maturation protein-1 (Blimp-1) has a protective role in inflammation-related disease. However, whether Blimp-1 can regulate cell pyroptosis and affect disease progression in sepsis is still unclear. Animal and cell models were established by the cecal ligation and puncture method and lipopolysaccharides (LPS)-induced RAW 264.7 cells, respectively, and the role of Blimp-1 in regulation inflammatory response and pyroptosis was verified. The changes of inflammation and pyroptosis in liver and lung tissues of septic mice were determined by the addition of TAK-242 (TLR4 inhibitor). Cell pyroptosis and the level of inflammation was detected after Blimp-1 knockdown and TAK-242 treatment in the cell model. The expression of Blimp-1 was continuously increased in a septic mice model. After treatment with TAK-242, the expression of Blimp-1, pyroptosis and inflammatory levels were reduced in mice. In the LPS-induced cell model, cell injury by knockout Blimp-1 was increased, and cell activity was restored after TAK-242 intervention. Overexpression of Blimp-1 relieved LPS-induced cellular inflammatory damage and pyroptosis. Our study had shown that Blimp-1 could improve septic damage by regulating the level of cellular inflammation and pyroptosis in sepsis.<\/jats:p>","DOI":"10.1177\/10815589241249994","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T01:01:46Z","timestamp":1713402106000},"page":"553-566","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["B-lymphocyte-induced maturation protein-1 inhibits inflammation and pyroptosis to alleviate sepsis injury"],"prefix":"10.1177","volume":"72","author":[{"given":"Zhizhen","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, Shihezi University School of Medicine\/The Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi, Xinjiang Uyghur Autonomous Region, P.R. 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