{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:40:24Z","timestamp":1789508424597,"version":"build-2803163510"},"reference-count":41,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>Multiple myeloma (MM), constituting 10% of hematological malignancies, poses significant morbidity and mortality, especially with skeletal involvement. Bisphosphonate use in MM may lead to severe hypocalcemia due to vitamin D deficiency (VDD), exacerbating bone-marrow plasma cell burden. We aimed to assess VDD prevalence and its impact on outcomes in MM patients. A retrospective cross-sectional analysis (2008\u20132018) of nationwide inpatient data identified adult MM hospitalizations with VDD using ICD-10-CM codes. Univariate and multivariate analyses were conducted to evaluate prevalence, demographics, and outcomes, with significance set at p\u2009&lt;\u20090.05. Among 330,175 MM hospitalizations, 3.48% had VDD. VDD was more prevalent among 50\u201375 year olds (61.72% vs 59.74%), females (53.36% vs 44.34%), Blacks (23.34% vs 22.94%), Whites (65.84% vs 65.79%), higher income brackets (26.13% vs 23.85%), and those with comorbidities like hypertension (71.12% vs 69.89%), dyslipidemia (42.47% vs 34.98%), obesity (13.63% vs 10.19%), and alcohol abuse (1.61% vs 1.34%). In regression analysis, VDD in MM patients correlated with higher morbidity (adjusted odds ratio (aOR): 1.24, 95% confidence interval (95% CI): 1.14\u20131.36) and major disability (aOR: 1.26, 95% CI: 1.20\u20131.30). MM patients with VDD exhibit worse outcomes, underscoring the importance of recognizing and managing VDD promptly. Further prospective studies are needed to validate our findings and explore the impact of vitamin D supplementation on MM patient outcomes.<\/jats:p>","DOI":"10.1177\/10815589241249998","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T01:02:41Z","timestamp":1713402161000},"page":"674-683","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence, outcomes, and complications of vitamin D deficiency among patients with multiple myeloma: Nationwide burden of disease"],"prefix":"10.1177","volume":"72","author":[{"given":"Rahul","family":"Gujarathi","sequence":"first","affiliation":[{"name":"Department of Hospital Medicine, University of Florida Health, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha Rakesh","family":"Lakhanpal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Emilio Aguinaldo College, Manila, Metro Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhila","family":"Chelikam","sequence":"additional","affiliation":[{"name":"Kansas City Heart Rhythm Institute (KCHRI), HCA Midwest Health System, Overland Park, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divesh","family":"Manjani","sequence":"additional","affiliation":[{"name":"Weiss Memorial Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simmy","family":"Lahori","sequence":"additional","affiliation":[{"name":"Pramukhswami Medical College, Karamsad, Anand, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Anusha","family":"Akella","sequence":"additional","affiliation":[{"name":"Department of Medicine, Kakatiya Medical College, Warangal, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanth Gumpu","family":"Shivashankar","sequence":"additional","affiliation":[{"name":"Adichunchanagiri Hospital, Bangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis Vino Dominic","family":"Savio","sequence":"additional","affiliation":[{"name":"Tianjin Medical University School of Basic Medical Sciences, Heping District, Tianjin, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdirazak Ibrahim","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Jackson Park Hospital & Medical Center, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navyatha","family":"Annareddy","sequence":"additional","affiliation":[{"name":"Nanjing Medical University, Nanjing, Jiangsu Province, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryak","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Quinnipiac University Frank H. 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