{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:22:08Z","timestamp":1777724528553,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Cancer Research Foundation of New York"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>Forty-one families with multiple cases of de novo acute myeloid leukemia (AML), B-cell acute lymphocytic leukemia (B-ALL), or both are presented. The families were randomly collected from physicians, genetic counselors, and other sources. Medical records were collected and reviewed for all families. In 17 of the families, a parent and child with acute leukemia were identified; and in 15 of the pairs, the parent and child were of the same sex. Nine grandparent\u2013grandchild affected pairs with AML-AML were identified, occurring in six families, and six of those pairs were also of the same sex. Anticipation was a common feature of these multigenerational pairs. Twenty families were identified with multiple siblings (none twins) with acute leukemia. This includes 16 sibling pairs and 4 sibling triples. The members of each sibling pair in the AML-AML group and in the B-ALL-B-ALL group were generally of roughly the same age. Curiously, this is not true of those in the AML-B-ALL group. Four of the 41 families had contributions to more than 1 family relationship category. Although inheritance in familial acute leukemia has usually been consistent with an autosomal dominant pattern, these data suggest that an X chromosome gene may be involved in some cases, perhaps in the pseudoautosomal region of the X chromosome as we have reported in familial Hodgkin lymphoma.<\/jats:p>","DOI":"10.1177\/10815589241262735","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T08:09:29Z","timestamp":1718266169000},"page":"842-847","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Families with multiple individuals with acute leukemia in their pedigrees"],"prefix":"10.1177","volume":"72","author":[{"given":"Peter H","family":"Wiernik","sequence":"first","affiliation":[{"name":"Cancer Research Foundation of New York, Chappaqua, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P","family":"Blakley","sequence":"additional","affiliation":[{"name":"Cancer Research Foundation of New York, Chappaqua, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice P","family":"Dutcher","sequence":"additional","affiliation":[{"name":"Cancer Research Foundation of New York, Chappaqua, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"707","article-title":"Familial leukemia: examination of 84 pedigrees","volume":"66","author":"Blakley MP","year":"2018","unstructured":"Blakley MP, Dutcher JP, Wiernik PH. Familial leukemia: examination of 84 pedigrees. J Invest Med 2018; 66: 707 (Abstract 22).","journal-title":"J Invest Med"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215453"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13880"},{"key":"e_1_3_3_5_2","first-page":"980","article-title":"Anticipation in familial leukemia","volume":"59","author":"Horwitz M","year":"1996","unstructured":"Horwitz M, Goode EL, Jarvik GP. Anticipation in familial leukemia. 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