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Brentuximab vedotin (BV) is an antibody\u2013drug conjugate (ADC) comprising a CD30-directed antibody. This review aimed to evaluate the efficacy and safety of BV for treating PTCL. We searched the PubMed, Embase, Cochrane Library, and Web of Science databases for studies evaluating the efficacy of BV alone or in combination with other drugs for treating PTCL. The primary outcome measures included objective response rate (ORR), complete remission (CR), progression-free survival (PFS), and overall survival (OS). The secondary outcomes included 5-year OS, 5-year PFS, and adverse events. 22 studies involving 1137 patients were included. These studies reported the use patterns of BV, ORR, CR, PFS, OS, and adverse events. The pooled ORR and CR rates were 68% (95% CI: 59%\u201375%) and 43% (95% CI: 34%\u201353%). For survival outcomes, the longest median PFS was 8.3\u2009months, and the longest median OS was 26.3\u2009months. The most common adverse event was peripheral neuropathy and neutropenia. 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