{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:42:21Z","timestamp":1788813741510,"version":"build-2803163510"},"reference-count":45,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Early onset colorectal cancer (EO-CRC) is increasing. We investigated the risk factors for ER-CRC compared to late onset colorectal cancer (LO-CRC). CRC patients between the years 1999 and 2021 were retrospectively evaluated. Data regarding demographics, comorbidities, malignancies, and mortality were collected. Data were retrieved using the MdClone platform from a large Health Maintenance Organization. The cohort was subdivided into EO-CRC (age\u2009\u2264\u200950\u2009years) and LO-CRC (age\u2009\u2265\u200951\u2009years) groups. 61,679 patients diagnosed with CRC were included in our analysis, 30,456 (49.4%) males, and 4891 (7.9%) Arabs, with an average age at diagnosis of 70.1\u2009\u00b1\u200913.1\u2009years. 5561 (9%) patients were included in the EO-CRC group. Over the last decades, higher rates of EO-CRC were diagnosed compared to the previous decade, 9.8% vs 8.3%, p\u2009&lt;\u20090.001. A higher percentage of EO-CRC patients were females (52.8% vs 50.4%), had a family history of CRC (9.9% vs 5.5%), were Arabs (18.7% vs 6.9%), and were smokers (32.7% vs 30.2%) compared to LO-CRC patients. Significantly lower rates of comorbidities such as ischemic heart disease, diabetes mellitus, hypertension, obesity, and iron deficiency anemia were found among EO-CRC patients, with a lower all-cause mortality (27.7% vs 63.1%, p\u2009&lt;\u20090.001). 348 (6.3%) of the EO-CRC patients had another Lynch-related cancer until age 50\u2009years compared to 45 (0.1%) at the LO-CRC. Young individuals with increased risk for CRC need special consideration and should be referred early for screening and endoscopic investigation, particularly those with a family history of CRC, smokers, and those of Arab ethnicity.<\/jats:p>","DOI":"10.1177\/10815589241296022","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T07:02:10Z","timestamp":1729148530000},"page":"261-267","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Early onset colorectal cancer, not just the age: Data from a large health organization"],"prefix":"10.1177","volume":"73","author":[{"given":"Naim","family":"Abu-Freha","sequence":"first","affiliation":[{"name":"The Institute of Gastroenterology and Hepatology, Soroka University Medical Center, Beer-Sheva, Israel"},{"name":"Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amani","family":"Beshara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Hillel Yaffe Medical Center, Hadera, The Rappaport Faculty of Medicine, Technion, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Winberg","sequence":"additional","affiliation":[{"name":"Medical School for International Health, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Weissmann","sequence":"additional","affiliation":[{"name":"Medical School for International Health, Ben-Gurion University of the Negev, Beer-Sheva, Israel"},{"name":"Soroka Clinical Research Center, Soroka University Medical Center, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bracha","family":"Cohen","sequence":"additional","affiliation":[{"name":"Soroka Clinical Research Center, Soroka University Medical Center, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Kopelman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Hillel Yaffe Medical Center, Hadera, The Rappaport Faculty of Medicine, Technion, Haifa, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zlata","family":"Lerner","sequence":"additional","affiliation":[{"name":"The Institute of Gastroenterology and Hepatology, Soroka University Medical Center, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Gordon","sequence":"additional","affiliation":[{"name":"Soroka Clinical Research Center, Soroka University Medical Center, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"bibr1-10815589241296022","doi-asserted-by":"publisher","DOI":"10.2174\/18735592MTEx9NTk2y"},{"key":"bibr2-10815589241296022","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"bibr3-10815589241296022","unstructured":"American Cancer Society. 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