{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:43:26Z","timestamp":1790711006453,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>Androgenetic alopecia (AGA) is more common in women than in men. This study aims to evaluate various androgenic hormones in women and to assess if free androgen index (FAI) can be used as a marker of hyperandrogenism in women. Forty women with AGA (defined as grade 1, 2, or 3) were taken as subjects, and 40 other healthy women were included as controls in the study. The serum concentrations of testosterone (T) and sex hormone-binding globulin (SHBG) were measured, and FAI was calculated accordingly and compared with the control group. Results revealed that there were significant differences in the mean value of the two indicators (testosterone and FAI) in cases as compared to the controls. While the level of SHBG tended to be higher in controls than AGA cases. FAI appeared to be a better biomarker to predict hyperandrogenism than testosterone and SHBG alone. It can be concluded that FAI could be considered a good marker for an individual\u2019s androgen and can be recommended to be a vital biomarker of AGA in females. It is recommended to apply these parameters in the routine investigations for female patients with AGA.<\/jats:p>","DOI":"10.1177\/10815589251348920","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T08:21:06Z","timestamp":1748593266000},"page":"111-119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Free androgen index and its relation with female pattern hair loss"],"prefix":"10.1177","volume":"74","author":[{"given":"Rania","family":"Hosny Mahmoud","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaimaa","family":"Thabet","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs &amp; Andrology, Faculty of Medicine, Fayoum University, Fayoum, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Ashraf Hosni","sequence":"additional","affiliation":[{"name":"Department of Dermatology, STDs &amp; Andrology, Faculty of Medicine, Fayoum University, Fayoum, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.31128\/AJGP-02-18-4498"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1942126"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.08.062"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13561"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-01357"},{"issue":"10","key":"e_1_3_2_7_2","article-title":"Diurnal variation of serum total testosterone in women: a single-center study from Basrah","volume":"15","author":"Algburi HD","year":"2023","unstructured":"Algburi HD, Sr Alhamza A, Mansour AA. Diurnal variation of serum total testosterone in women: a single-center study from Basrah. 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Validity of serum testosterone, free androgen index, and calculated free testosterone in diagnosing hyperandrogenism. J Clin Endocrinol Metab 2012; 97(2): 514\u2013521. Blume-Peytavi U, Blumeyer A, Tosti A, et al. S1 guideline for diagnostic evaluation in androgenetic alopecia in men, women and adolescents. 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Role of serum androgens and prostate-specific antigen in male patients with androgenetic alopecia. 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