{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:24:36Z","timestamp":1777724676391,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    Single-nucleotide polymorphisms may alter severe acute respiratory syndrome virus 2 (SARS-CoV-2) binding or entry and increase lung or other organ tissue damage in the most prevalent genes,\n                    <jats:italic toggle=\"yes\">angiotensin-converting enzyme 2<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">ACE2)<\/jats:italic>\n                    and its close relative,\n                    <jats:italic toggle=\"yes\">ACE1<\/jats:italic>\n                    . The goal of this study was to look at the severity of the illness, the involvement of the\n                    <jats:italic toggle=\"yes\">ACE2<\/jats:italic>\n                    gene polymorphism, and its vulnerability to coronavirus disease 19 (COVID-19) infection. Forty patients, both male and female, with a diagnosis of COVID-19, ages 25 to 70, participated in this retrospective case-control research, which was divided into two groups (Group II: diagnosed as mild COVID-19, and Group III: diagnosed with severe COVID-19) and 20 individuals as a control group. Compared to groups II and I, group III\u2019s\n                    <jats:italic toggle=\"yes\">ACE2<\/jats:italic>\n                    serum level was considerably lower (p\u2009&lt;\u20090.05). Ferritin, D-dimer, procalcitonin, interleukin-6 (IL-6), and fibrinogen all showed a significant negative connection (p\u2009&lt;\u20090.05). Significant positive correlations were found with oxygen saturation and relative lymphocyte presence (p\u2009&lt;\u20090.05). Serum\n                    <jats:italic toggle=\"yes\">ACE2<\/jats:italic>\n                    and ferritin levels can significantly predict patients with SARS-CoV-2, respectively, at cutoff values of 23 and 75, with 90% and 92% sensitivity, 85% and 90% specificity. C-reactive protein, ferritin, procalcitonin, IL-6, and D-dimer showed a significant increase in patients with the GG genotype than the AA and GA genotypes in groups II and III (p\u2009&lt;\u20090.05).\n                    <jats:italic toggle=\"yes\">ACE2<\/jats:italic>\n                    is the primary receptor for SARS-CoV-2 entrance into many bodily cells and is crucial to the pathophysiology of COVID-19. It may be a useful biomarker for assessing the risk of acquiring SARS-CoV-2, as demonstrated by the fact that COVID-19 patients had much lower blood levels of the virus than healthy controls.\n                  <\/jats:p>","DOI":"10.1177\/10815589251348921","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T06:47:53Z","timestamp":1748933273000},"page":"177-187","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Polymorphism of\n                    <i>Angiotensin-Converting Enzyme 2 Gene<\/i>\n                    (\n                    <i>rs 2285666<\/i>\n                    ) and its susceptibility to COVID-19 infection and severity of the disease"],"prefix":"10.1177","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1016-9200","authenticated-orcid":false,"given":"Hend Samir Abdelkader","family":"Elshewaikh","sequence":"first","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gihan Farouk","family":"Attia","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesam Salah Mohamed","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragia Samir","family":"Sharshar","sequence":"additional","affiliation":[{"name":"Chest Diseases Department, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina A","family":"Ali","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191912622"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/v13061081"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-020-00408-4"},{"key":"e_1_3_3_5_2","article-title":"Serum ACE2 and S19P gene polymorphism in Egyptian patients with COVID-19 infection: correlation with disease severity","volume":"14","author":"Gaber DA","year":"2024","unstructured":"Gaber DA, Shokr M, Shaker O, et al. Serum ACE2 and S19P gene polymorphism in Egyptian patients with COVID-19 infection: correlation with disease severity. Eur J Intern Med 2024; 14: 58\u201346.","journal-title":"Eur J Intern Med"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1139\/gen-2020-0124"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0000000000000436"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-023-00501-8"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27160"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1672"},{"key":"e_1_3_3_11_2","first-page":"120","article-title":"A comparative evaluation of four DNA extraction protocols from whole blood sample","volume":"62","author":"Ghaheri M","year":"2016","unstructured":"Ghaheri M, Kahrizi D, Yari K, et al. A comparative evaluation of four DNA extraction protocols from whole blood sample. 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TEJB 2023; 17: 30\u201339.","journal-title":"TEJB"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00317"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.047049"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2020.04.037"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.836516"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0288178"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1058120"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20200163"}],"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589251348921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10815589251348921","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589251348921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:29Z","timestamp":1777459229000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10815589251348921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1177\/10815589251348921"],"URL":"https:\/\/doi.org\/10.1177\/10815589251348921","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,28]]}}}