{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:13:59Z","timestamp":1793657639327,"version":"4.5.1"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Sarcopenia, a progressive loss of skeletal muscle mass and strength, is an emerging yet under-recognized complication in autoimmune diseases. Although extensively studied in conditions such as rheumatoid arthritis and systemic lupus erythematosus, its prevalence and impact in Sj\u00f6gren\u2019s syndrome (SS) remain largely unexplored. This study aimed to assess muscle mass and strength in patients with SS, investigate the prevalence of probable sarcopenia and sarcopenia, and identify associated risk factors. A cross-sectional study included 79 SS patients and 72 healthy controls. Handgrip strength (HGS) and bioelectrical impedance analysis were used to assess muscle function. Probable sarcopenia and sarcopenia were defined according to the 2018 EWGSOP2 criteria and specific cutoffs for the Turkish population. Probable sarcopenia was significantly more prevalent in SS patients (63.6%) compared to controls (40.5%, p\u2009=\u20090.005), while sarcopenia was detected in 53.7% of SS patients vs 29.4% of controls (p\u2009=\u20090.01). Older age, lower HGS, reduced skeletal muscle mass index, and delayed diagnosis were significantly associated with probable sarcopenia. Sarcopenia is a prevalent yet overlooked complication in Sj\u00f6gren\u2019s syndrome, emphasizing the need for routine muscle function assessments in clinical practice. Targeted interventions and a multidisciplinary approach are crucial to mitigating its impact and improving long-term patient outcomes.<\/jats:p>","DOI":"10.1177\/10815589251349099","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T07:09:41Z","timestamp":1749452981000},"page":"34-42","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling sarcopenia in Sj\u00f6gren\u2019s syndrome: A hidden comorbidity"],"prefix":"10.1177","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2523-1695","authenticated-orcid":false,"given":"Reyhan","family":"Bilici","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Konya City Hospital, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1356-6700","authenticated-orcid":false,"given":"Esra","family":"\u00c7ataltepe","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Sat\u0131\u015f","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna","family":"G\u00f6ker","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-021-00728-6"},{"key":"e_1_3_2_3_2","article-title":"Digestive involvement in primary sjogren\u2019s syndrome: analysis from the sjogrenser registry","volume":"38","author":"Melchor S","year":"2020","unstructured":"Melchor S, S\u00e1nchez-Piedra C, Fern\u00e1ndez Castro M, et al. Digestive involvement in primary sjogren\u2019s syndrome: analysis from the sjogrenser registry. Clin Exp Rheumatol 2020; 38(Suppl 126):S110\u2013S115.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182329d9c"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/err.err_25_17"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-018-1139-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165678"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1991.260.5.E727"},{"key":"e_1_3_2_9_2","article-title":"Omega-3 and omega-6 fatty acids in primary Sj\u00f6gren\u2019s syndrome: clinical meaning and association with inflammation","volume":"38","author":"Castrej\u00f3n-Morales CY","year":"2020","unstructured":"Castrej\u00f3n-Morales CY, Granados-Portillo O, Cruz-Bautista I, et al. Omega-3 and omega-6 fatty acids in primary Sj\u00f6gren\u2019s syndrome: clinical meaning and association with inflammation. Clin Exp Rheumatol 2020; 38(Suppl 126):S34\u2013S39.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-021-01800-7"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/9tnksi"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102867"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-019-04354-0"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000001669"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06427-1"},{"issue":"11","key":"e_1_3_2_16_2","article-title":"Analysis of 31 cases of female Sjogren\u2019s syndrome patients with changes in muscle mass","volume":"7","author":"Zhang Y.","year":"2020","unstructured":"Zhang Y. Analysis of 31 cases of female Sjogren\u2019s syndrome patients with changes in muscle mass. Open Access Library J 2020; 7(11): e6872.","journal-title":"Open Access Library J"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.18051\/UnivMed.2024.v43.340-348"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210571"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afz046"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.02.002"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2018.1499081"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000001669"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2018.03.046"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2018.1510565"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2024-001204"}],"container-title":["Journal of Investigative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589251349099","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10815589251349099","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10815589251349099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:40:29Z","timestamp":1777459229000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10815589251349099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/10815589251349099"],"URL":"https:\/\/doi.org\/10.1177\/10815589251349099","relation":{},"ISSN":["1081-5589","1708-8267"],"issn-type":[{"value":"1081-5589","type":"print"},{"value":"1708-8267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}