{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:24:45Z","timestamp":1777724685153,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>The aim of this study is to define the frequency and predictors of axial spondyloarthritis and treatment options in patients with Sj\u00f6gren syndrome. In our study, the frequency of spondyloarthritis according to the International Association for the Assessment of Spondyloarthritis (ASAS) criteria was investigated in 84 patients who were diagnosed with primary Sj\u00f6gren syndrome according to the 2016 ACR \/ EULAR (American College of Rheumatology\/European Association of Rheumatology Associations) classification criteria in the Internal Medicine Rheumatology clinic of our hospital between November 2023 and January 2025. Patients\u2019 age, gender, HLAB-27, anti-nuclear antibody (ANA), anti-SSA, anti-SSB, inflammatory back pain, presence of sacroiliitis on sacroiliac joint magnetic resonance imaging (MRI), medications used, and Sj\u00f6gren syndrome complications were recorded retrospectively. A total of 94% of the patients were female and 6% were male. The median age was 51\u2009years. Axial spondyloarthritis (axSpA) was detected in 27% of the patients. Among those who developed axial spondyloarthritis, 15 patients received nonsteroidal anti-inflammatory drugs (NSAIDs), 5 patients received sulfasalazine, 1 patient received methotrexate, 1 patient received TNF (tumor necrosis factor) inhibitor, and 1 patient received secukinumab treatment. Four of those who received sulfasalazine had anterior uveitis and 1 had enthesitis. The only variable found to be associated with the presence of axial spondyloarthritis in primary Sj\u00f6gren syndrome was ANA (p value: 0.006). Spondyloarthritis is not uncommon in primary Sj\u00f6gren syndrome. ANA has been found to be associated with the presence of axial spondyloarthritis in primary Sj\u00f6gren syndrome and has the potential for further research.<\/jats:p>","DOI":"10.1177\/10815589251349102","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T07:08:43Z","timestamp":1749452923000},"page":"140-145","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The frequency, predictors, and treatment options of spondyloarthritis in primary Sj\u00f6gren\u2019s syndrome: a single-center experience"],"prefix":"10.1177","volume":"74","author":[{"given":"Beliz","family":"Karata\u015f","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Binali Y\u0131ld\u0131r\u0131m University Meng\u00fccek Gazi Training and Research Hospital, Erzincan, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,7,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-024-03262-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06053-x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205375"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2006.21.2.116"},{"issue":"6","key":"e_1_3_3_6_2","first-page":"434","article-title":"Ankylosing spondylitis with primary Sj\u00f6gren\u2019s syndrome: the first two case-reports","volume":"65","author":"Golstein MA","year":"1998","unstructured":"Golstein MA, Steinfeld S. Ankylosing spondylitis with primary Sj\u00f6gren\u2019s syndrome: the first two case-reports. Rev Rhum Engl Ed 1998; 65(6): 434\u2013436.","journal-title":"Rev Rhum Engl Ed"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","unstructured":"Lin CY Chao TC Chiu CH et al. Coexistence of sacroiliitis and facet joint syndrome in an aged lady of Sj\u00f6gren\u2019s syndrome: unexpected involvement of symphysis pubis. ijclinmedcasereports.com. doi: 10.46998\/IJCMCR.2024.45.001110.","DOI":"10.46998\/IJCMCR.2024.45.001110"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2018.30.98.15588"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.200189"},{"key":"e_1_3_3_10_2","article-title":"Sj\u00f6gren\u2019s syndrome and ankylosing spondylitis association: a case-based review","author":"Slouma M","unstructured":"Slouma M, Mehmli T, Hannech E, et al. Sj\u00f6gren\u2019s syndrome and ankylosing spondylitis association: a case-based review. Curr Rheumatol Rev. Epub ahead of print 5 November 2024.","journal-title":"Curr Rheumatol Rev"},{"issue":"1","key":"e_1_3_3_11_2","first-page":"43","article-title":"What is the sacroiliitis frequency in patients with primary Sj\u00f6gren syndrome?","volume":"50","author":"Karabulut G","year":"2011","unstructured":"Karabulut G, Kitap\u00e7\u0131o\u011flu G, Arg\u0131n M, et al. What is the sacroiliitis frequency in patients with primary Sj\u00f6gren syndrome? 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Comparison of IL-23 receptor gene polymorphisms in patients with primary Sj\u00f6gren syndrome, ankylosing spondylitis and ankylosing spondylitis with Sj\u00f6gren\u2019s syndrome. 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